DIC

PCC or other factor replacement is not helpful in treatment because it causes more thrombus formation, “fueling the fire”.- Susan Brion MD

DIC

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DIC is a syndrome that involves widespread, unregulated activation of the coagulation system, presenting with elevated INR and D-Dimer and decreased platelet counts and fibrinogen level. The decreased fibrinogen level is what sets it apart from other bleeding disorders, a give-away in the stem. It can cause thrombotic/ischemic complications as well as internal and external hemorrhage...

Although it may present with hemorrhage, thrombosis, or both, certain disease entities tend to produce one more than the other. For example, patients with DIC from sepsis tend to present with ischemic/thrombotic complications. Patients with DIC from leukemia tend to display hemorrhagic complications.

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Last Updated : Monday, December 19, 2022