Professor Sarah Walker, Professor Jeremy Farrar and Sarah Crofts explain more about antibodies and how our immune system protects us from infection:
An antibody is a complex protein made by a particular class of immune cells called B-cells during the adaptive immune response. The adaptive immune system, which originated in jawed fishes and is present in all higher vertebrates, confers a form of molecular memory that is both highly specific and incredibly diverse in its ability to recognize molecules from foreign sources including pathogens.
Here we’ll take a look at the biological mechanisms that allow for the incredible functional diversity of antibodies and consider the various ways that antibodies can be classified.
The road leading to the discovery of antibodies and their use as essential research reagents began in the early 18th century with the first smallpox inoculation studies. By transferring material from the sores of human smallpox patients into scratches made in the skin of healthy individuals, it was shown to be possible to protect against future smallpox infection. Importantly, these experiments provided some of the very earliest insights into the mechanisms underlying immunity.
Antibodies are one of the most commonly used research tools in scientists’ pockets. They allow researchers to identify and isolate very specific biological targets.
While more studies are needed to confirm the findings, discovering that these markers correlate with immune protection has implications for future COVID-19 vaccine research. It means that researchers now can measure whether a new COVID-19 vaccine might work — without necessarily having to repeat large-scale efficacy studies.
Antibodies are great and all, but macrophages, B cells, and helper T cells deserve some attention too.
A new study might shed light on why children experience the virus differently.
A network of scientists is chasing the pandemic’s holy grail: an antibody that protects against not just the virus, but also related pathogens that may threaten humans.
Antibodies are specialized, Y-shaped proteins that bind like a lock-and-key to the body's foreign invaders — whether they are viruses(opens in new tab), bacteria, fungi or parasites. They are the "search" battalion of the immune system's search-and-destroy system, tasked with finding an enemy and marking it for destruction.
These immune proteins help us to fight off viruses and bacteria, and antibody-based medicines can be useful in treating infections and other diseases. Amgen has deep expertise in immunology and antibody design. Here’s an overview of the underlying biology and science.
Human Antibodies is an international journal designed to bring together all aspects of human hybridomas and antibody technology, along with factors that modulate host antibody repertoire and effectiveness, such as vaccines, infectious agents, and microbiome.
Antibodies.com supplies high-quality research tools to life scientists at cost-effective prices.