Glucagon-like peptide 1

It has been absolutely fascinating to see how a peptide discovered for its ability to stimulate insulin secretion has developed into a class of drugs with hitherto unseen effectiveness on diabetes progression and overweight/obesity - Jens J. Holst

Glucagon-like peptide 1

image by: Astrid Gerardi

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Glucagon-like peptide-1: Are its roles as endogenous hormone and therapeutic wizard congruent?

Glucagon-like peptide-1 (GLP-1) is a peptide derived from differential processing of the precursor for the hormone glucagon. It is secreted predominantly by endocrine cells in the gut epithelium in response to nutrient stimulation. Studies from the last 35 years have given us an idea about its physiological functions. On the basis of some of its many actions, it has also been developed into a pharmaceutical agent for the treatment of obesity and type 2 diabetes (T2DM). It is currently positioned as the most effective anti-obesity agent available and is recommended in both national and international guidelines as an effective second-in line treatment for T2DM, in particular in patients with…

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Last Updated : Tuesday, March 21, 2023