Contrary to popular belief, insulin is not needed for glucose uptake and utilization in man - Anssi H Manninen, 2004


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Glucagon: The Name Says It All, or Not!

Glucagon, a hormone synthesized in pancreatic α cells, primarily promotes the breakdown of glycogen to glucose in the liver. Glucagon excess has played a primary role in the metabolic perturbations associated with diabetes, making it an attractive therapeutic target. During the last decade, glucagon was shown to play important roles in pancreatic development, insulin cell function, and metabolic responses to prolonged fasting, exercise, lipid metabolism, hepatic energy state, and hepatocyte survival. However, antagonizing glucagon action as a possible therapy for diabetes has several unintended effects.

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Last Updated : Wednesday, March 22, 2023