Methotrexate an old drug with new tricks - Yosra Bedoui et al


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Study investigates rates of adverse events for common rheumatoid arthritis drug

Methotrexate is a common drug with a long history; for the past 40 years, it's been used to treat a range of diseases. Today it is the most commonly used drug for systemic rheumatic diseases worldwide and is the first drug a physician will prescribe for a patient with rheumatoid arthritis. But despite its use by millions of people, there is not robust data on the rates of the side effects of the drug. Observational studies have suggested that methotrexate may elevate a person's risk of a variety of adverse events, including liver toxicity, anemia and difficulty in breathing, but the magnitude of risk was unknown.

Taking advantage of data from the Cardiovascular Inflammation Reduction…

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Last Updated : Wednesday, January 20, 2021