Lambert-Eaton Myasthenic Syndrome

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Lambert-Eaton Myasthenic Syndrome
Lambert-Eaton Myasthenic Syndrome

image by: Lambert-Eaton News

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Not All Superheroes Wear Capes

I wasn’t diagnosed with Lambert-Eaton myasthenic syndrome (LEMS) until my sons were grown.

Upon his return from serving in the Navy, one of my sons remarked how happy he was that I could make weekend plans with friends instead of “just recovering each weekend after working all week” like I did when he was growing up. For the most part, my sons knew their mom before diagnosis. Later, they saw the positive results of treatments.

Last week, that same son had a medical emergency stemming from two common illnesses: severe tonsillitis and strep throat. His tonsils appeared abscessed on a CT scan. Additional tests showed that the strep infection had taken hold in his bloodstream.

His…

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 A loss for the rest of us’: An FDA approval is a boon for a drug maker, but could come at a major cost for patients

The 65-year-old from Elkton, Va., says she has her life back, thanks to the stunning efficacy of a cheap, but unapproved, chemical called 3,4-DAP. It’s a medication she would not have but for the largesse of a tiny, family-run drug maker that has been giving it out, for free, for decades. But Moored, along with others who share her rare neuromuscular disorder, are concerned that their fortunes could change.

 Not All Superheroes Wear Capes

My son and I have answers and a plan. I can look ahead to his surgery and be grateful that this will be behind him. A rare disease is never behind your child. You are the superheroes of parents everywhere.

Lambert-Eaton News

Lambert-Eaton News is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment.

LEMS.com

Comprehensive online resource for patients and their families regarding Lambert-Eaton Myasthenic Syndrome (LEMS).

American Association of Neuromuscular & Electrodiagnostic Medicine

Lambert-Eaton myasthenic syndrome (LEMS) is a syndrome of weakness and fatigue due to an auto-immune process. LEMS is often associated with cancer, particularly lung cancer. There may be symptoms of LEMS before the cancer is diagnosed and once the diagnosis of LEMS has been made, the patient must be followed for the development of cancer.

Muscular Dystrophy Association

The disease is named for Edward Lambert and Lee Eaton, neurologists at the Mayo Clinic in Rochester, Minn., who first described myasthenic syndrome in the 1950s and '60s.

HealthEngine

Lambert-Eaton syndrome is a disease of the neuromuscular junction. A syndrome is a constitution of symptoms or conditions that occur together with the clinical significance that there may be presence of a certain disease.

NHS

In about 50% of people with LEMS, the disease is triggered by an underlying lung cancer (the type associated with smoking). These people usually develop the disease in middle age or later. There is no obvious trigger in the other 50% of patients with LEMS who don't have cancer. This form of the disease may start at any age.

NORD

LEMS is characterized by weakness and fatigue especially of the pelvic and thigh muscles. The disease may affect the patient’s ability to engage in strenuous exercise and may make such activities as climbing stairs or walking up a steep walkway difficult. Onset is gradual, typically taking place over several weeks to many months.

Patient

LEMS results from an autoimmune attack directed against the P/Q subtype of voltage-gated calcium channels (VGCCs) on the presynaptic motor nerve terminal. These channels are also found in high numbers in the tumour cells associated with LEMS - small cell cancer of the lung (SCCL). It is thought that antibodies are produced against the tumour VGCCs but are then also responsible for the resulting attack on non-cancerous cells and their sequelae. This is supported by animal studies.

PatientsLikeMe

Common symptoms reported by people with Lambert-Eaton Myasthenic Syndrome...

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