Sickle Cell Trait

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Sickle Cell Trait
Sickle Cell Trait

image by: TS3 Sickle Cell Trait Foundation

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The health implications, good and bad, of sickle cell trait

...I thought it might be interesting to look at sickle cell trait, the carrier state for sickle cell. This is normally considered to be a benign and completely harmless condition but evidence is accumulating that this may not be the whole story.

If you inherit two copies of the sickle cell mutation, one from each of your parents, you have sickle cell disease, with all the problems and complications we know about. However, if you inherit only one copy of the sickle cell mutation, from either your mum or dad, and a normal haemoglobin gene from the your other parent, then you have sickle cell trait; your blood looks normal down the microscope, you are not anaemic and you do not get painful…

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Resources

 The health implications, good and bad, of sickle cell trait

But there is more to this story – let’s begin with the positives. Under certain circumstances, being a carrier for sickle cell can also be a positive advantage. This is because the mutation provides a major degree of protection against malaria. As a result, carrier rates for sickle cell have reached very high levels in populations regularly exposed to this devastating disease.

The As One Foundation

The As One Foundation, established in 2007 as a non-profit 501(c)(3) organization provides sickle cell trait education presentations and free testing to prevent adverse health effects and even death due to sickle cell trait in young athletes, a.k.a. exertional sickling.

TS3 Sickle Cell Trait Foundation

At TS3 FOUNDATION we’re raising funds and promoting initiatives to serve the people who need them most. We believe in taking action with urgency in order to raise public awareness about sickle cell trait issues facing today’s society. Please join us by supporting our efforts to make a measurable difference in the lives of others.

Sickle Cell Society

Sickle cell trait is found in 1 in 4 West Africans and 1 in 10 Afro-Caribbeans, and is also found in people who originate from the Mediterranean, Asia and the Middle East. It is less common in white European’s, although with the ever growing diversity of the population this will change.

CDC

Some people with SCT have been shown to be more likely than those without SCT to experience heat stroke and muscle breakdown when doing intense exercise, such as competitive sports or military training under unfavorable temperatures( very high or low) or conditions. Studies have shown that the chance of this problem can be reduced by avoiding dehydration and getting too hot during training.

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