Cytokine Storm
This syndrome occurs unfortunately every day in ICUs, both in pediatrics and adults across the planet, as a result of a whole variety of conditions that go under-diagnosed and therefore under-treated. However, COVID-19 is changing that - Dr. Randy Cron
image by: José Mário Tran
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What Is The Cytokine Storm And Why Is It So Deadly For Coronavirus Patients?
When we get sick we trust our immune system to protect us, but what happens when that system goes awry and ends up killing patients? COVID-19 is shedding new light on how viruses can kick some patient’s immune system into overdrive to deadly effect in what is known as a cytokine storm syndrome.
In short, our immune system by and large is incredibly effective at working around the clock to keep a myriad of infections and diseases at bay while simultaneously being able to identify between outside invaders and our own cells and effectively prioritise what to attack and what to protect. However, occasionally, either due to genetic factors or rampant viral infections like COVID-19, our…
Resources
Blocking the deadly cytokine storm is a vital weapon for treating COVID-19
The killer is not the virus but the immune response. The current pandemic is unique not just because it is caused by a new virus that puts everyone at risk, but also because the range of innate immune responses is diverse and unpredictable. In some it is strong enough to kill. In others it is relatively mild.
How Covid Sends Some Bodies to War With Themselves
Many Covid-19 patients may be dying from their immune response to the virus, not from the virus itself. Can science figure out how to save them?
What it feels like to survive COVID-19’s dreaded “cytokine storm”
A doctor and coronavirus patient in recovery describes his experience surviving COVID-19's worst side effect.
AI Uncovers a Potential Treatment for Covid-19 Patients
Software suggested an arthritis drug might quell an out-of-control immune response that damages the lungs. Now it's being tested in a clinical trial.
Proteins may halt the severe cytokine storms seen in COVID-19 patients
Team designs antibody-like receptor proteins that can bind to cytokines, as possible strategy for treating coronavirus and other infections.
The Coronavirus Patients Betrayed by Their Own Immune Systems
A “cytokine storm” becomes an all-too-frequent phenomenon, particularly among the young. But treatments are being tested.
What Is The Cytokine Storm And Why Is It So Deadly For Coronavirus Patients?
When we get sick we trust our immune system to protect us, but what happens when that system goes awry and ends up killing patients? COVID-19 is shedding new light on how viruses can kick some patient’s immune system into overdrive to deadly effect in what is known as a cytokine storm syndrome.
What it feels like to survive COVID-19’s dreaded “cytokine storm”
A doctor and coronavirus patient in recovery describes his experience surviving COVID-19's worst side effect.
Why Covid-19 is so dangerous for older adults
In other words, it’s not just a sluggish response to infections that can harm older adults; the immune system’s overreaction to an invader can also kill, Leng said. “The cause of death of this virus is, No. 1, respiratory failure, and then No. 2, probably the cytokine storm.”
All about cytokines in less than 400 words
Cytokines are little messenger molecules that are involved in tons of different physiologic and pathologic conditions. You’ll hear about them in such excruciating detail that it can be easy to lose sight of the big picture.
Cytokine storms are the most disturbing COVID-19 symptom yet
There are so many perplexing questions about COVID-19 but the one that seems to stump everyone is why some people are dropping dead when they get this virus and others are completely asymptomatic.
Haywire Immune Response Eyed in Coronavirus Deaths, Treatment
Researchers are looking at treatments to suppress ‘cytokine storm,’ increasingly linked to the most severe Covid-19 cases.
He ran marathons and was fit. So why did Covid-19 almost kill him?
Among the many mysteries of Covid-19 is why relatively healthy young people suddenly become critically ill — or die.
How doctors can potentially significantly reduce the number of deaths from Covid-19
We already have medicines for treating cytokine storm syndrome, the immune response that’s killing many who die of Covid-19.
How quieting 'blood storms' could be key to treating severe COVID-19
In some coronavirus patients, the body turns its attacks on itself. Anti-inflammatory drugs may be able to help stop this friendly fire
Immune ‘Boosters’ Ignore the Immune System’s Best Quality: Balance
We could stand to learn some lessons from our own immune systems about how we decide when to act and when to lay low.
Modulation of Covid-19 cytokine storm by tocilizumab
By the majority of the reported clinical studies, the use of tocilizumab in Covid-19 infection appears promising in specific cases of the cytokine storm. Conflicting results prevent the recommendation of IL inhibitors against Covid-19 infection by many health organizations.
The COVID-19 Cytokine Storm; What We Know So Far
COVID-19 infection is accompanied by an aggressive inflammatory response with the release of a large amount of pro-inflammatory cytokines in an event known as “cytokine storm.” The host immune response to the SARS-CoV-2 virus is hyperactive resulting in an excessive inflammatory reaction.
This theory might explain “Covid toes” and other mysteries of the disease
Bradykinin storms are the hottest new hypothesis for why Covid-19 can wreak havoc on the body.
Why Some COVID-19 Patients Crash: The Body's Immune System Might Be To Blame
Now doctors and researchers are increasingly convinced that, in some cases at least, the cause is the body's own immune system overreacting to the virus. The problem, known broadly as a "cytokine storm," can happen when the immune system triggers a runaway response that causes more damage to its own cells than to the invader it's trying to fight.
What Is The Cytokine Storm And Why Is It So Deadly For Coronavirus Patients?
When we get sick we trust our immune system to protect us, but what happens when that system goes awry and ends up killing patients? COVID-19 is shedding new light on how viruses can kick some patient’s immune system into overdrive to deadly effect in what is known as a cytokine storm syndrome.
International Cytokine and Interferon Society
The International Cytokine and Interferon Society (formerly ISICR and ICS) is a non-profit organization of over 600 scientists devoted to research in the fields of cytokine, interferon and chemokine cell biology, molecular biology, biochemistry and the clinical use of these biological response modifiers.
Cytokine
An Official journal of the International Cytokine and Interferon Society.
Cytokines.com
The Cytokine Core Laboratory offers an extensive list of human, mouse, and rat cytokine, chemokine and growth factor assays. Two complementary assay platforms are available, each which have their own unique advantages and disadvantages.
Cells Talk
The COPE Encyclopedia is unique because it is the only existing resource that puts the focus on highlighting the manifold interactions between cells and the messages they exchange by using hormones and hormone-like proteins called cytokines.
Interferons
Interferons are glycoprotein cytokines secreted by host lymphocytes in response to pathogens. Interferons activate or upregulate immune cells by interacting with receptors that activate signal transducer and activator of transcription (STAT) signalling complexes. This ultimately leads to clearance of the pathogen or clearance of tumour cells from the organism.
Journal of Interferon & Cytokine Research
Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.
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