An unprecedented public health crisis has led to an unprecedented global response -


image by: Dr Tiago Simon - Pneumologia e Medicina do Sono

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The best treatments we currently have for COVID-19

...There’s a long road ahead before everyone is vaccinated—around the world, not just in the United States—but the good news for those who get COVID-19 between now and then is that we know more about treating the disease now than we did in the early months of the pandemic. Here’s a breakdown of the best treatments we have for COVID-19.


Some of the most promising COVID-19 treatments have relied on giving the patient’s own immune system a boost using antibodies from other people.

Once someone is exposed to a pathogen, their immune system tries to develop antibodies against it, but the process of developing one’s own antibodies can take…

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  The best treatments we currently have for COVID-19

We’ve come a long way since the beginning of the pandemic.

4 changes doctors have made to better treat Covid-19 patients

“There is a lot that has changed. We’ve made amazing progress,” Dr. Daniel Kuritzkes, the chief of the infectious disease division at Brigham and Women’s Hospital and a professor at Harvard Medical School, told me in a phone interview last week. “Many of us do have the sense that we’ve gotten better at what we’re doing, and we are seeing less mortality, even among older hospitalized patients with Covid-19.”


Despite initial fears, evidence from retrospective observational studies supports the inhibition of the renin-angiotensin system as an emerging pathway to delay or moderate angiotensin II-driven lung inflammation - Rodolfo Pedro Rothlin


RECOVERY trial finds aspirin does not improve survival for patients hospitalised with COVID-19.


RECOVERY trial finds no benefit from azithromycin in patients hospitalised with COVID-19


Inhaled corticosteroids in virus pandemics: a treatment for COVID-19? - Dan V Nicolau & Mona Bafadhel


RECOVERY trial finds colchicine does not improve survival for patients hospitalised with COVID-19

Convalescent Plasma

Among patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes - Recovery Trial


Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19 - Recovery Trial


No clinical benefit from use of hydroxychloroquine in hospitalised patients with COVID-19 - Recovery Trial


The antiparasitic drug was thought to be a potential treatment for COVID-19, but there isn't sufficient evidence to recommend its use, despite widespread support online - Gordon Dent


Vague success claims aside, a handful of others have written about the possible ways melatonin might reduce the severity of a SARS-CoV-2 infection, and there's currently a clinical trial running in the U.S. to examine this possibility. However, “at this time, early SARS-CoV-2 intervention with melatonin is not well supported,” says Cesar Borlongan, a neurologist at the University of South Florida. Much more rigorous research is needed to determine whether the molecule can do more than regulate sleep-wake cycles.

Monoclonal Antibodies

RECOVERY trial finds Regeneron’s monoclonal antibody combination reduces deaths for hospitalised COVID-19 patients who have not mounted their own immune response.


Because the disease affects different people in different ways. Anything that works on even part of it, can and will be used to save lives and shorten the duration of the disease, when dosed on the right patients at the right time in the right method. That is the goal here. Anything that helps that happen is worth celebrating _ Shazbot


Parallels drawn with early data on hydroxychloroquine.


The antiviral drug Remdesivir is the first step in what we project will be better and better drugs coming along to treat COVID-19 - Anthony Fauci


The other thing to emphasize... is that none of these drugs directly alter the pandemic itself. They will save more lives when people get infected, but we really need to try to keep more people from getting infected in the first place, especially now that it’s become more apparent that social distancing and as trivial a thing as public use of face masks can help. We could be mitigating this pandemic with such measures in this country, but in too many regions we don’t seem to be doing that. Eventually, though, what makes this disease go away will be a vaccine.


Tocilizumab reduces deaths in patients hospitalised with COVID-19 - Recovery Trial


No mRNA vaccine has ever been mass-produced to fight a disease — coronavirus would be the first - Matthew Rozsa

Vitamin D

We’re scientists – we believe in data. We feel that the data today suggests that vitamin D will not protect against Covid outcomes. We would be happy to entertain any data that suggests otherwise - Dr Brent Richards


Zinc is no COVID-19 magic bullet, but it has shown to help with other coronaviruses - Todd Neff

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