Johnson & Johnson

New vaccines are falling short of the spectacular expectations set by Pfizer and Moderna. The world still needs them - Sarah Zhang

Johnson & Johnson

image by: Oscar Mario Beteta


When Pfizer and Moderna reported data late last year, we were looking to see whether the vaccine candidates could handle the original strain of the coronavirus. Both proved to be more than 94% efficacious. Johnson & Johnson -- and others reporting now and in the future -- are in a different situation. Their vaccines came up against the new variants as well. But, like Pfizer and Moderna, these companies designed their vaccines to target the original virus. All of this means we shouldn't be surprised if its efficacy is lower than that of Pfizer and Moderna.

Johnson & Johnson's trial spanned several regions, and the company separated efficacy rates accordingly. This makes it easier to examine its performance against variants. The vaccine produced 72% efficacy in the U.S., 66% efficacy in Latin America, and 57% efficacy in South Africa. New strains are increasing in the U.S. But the Brazil strain has gained ground in Latin America. And the South African strain originated in South Africa. That probably explains -- at least somewhat -- why the vaccine candidate demonstrated lower efficacy in those areas.

Pfizer and Moderna recently tested their vaccines in vitro and said they can prevent the new strains. But we don't have an efficacy readout from a clinical trial setting. That makes it difficult to perfectly compare Johnson & Johnson's vaccine performance to that of Pfizer and Moderna in today's coronavirus situation.

So, let's turn our focus back to Johnson & Johnson alone. Considering the increase in variants during the time of the pivotal trial, I think that the vaccine candidate produced decent results.

From "decent" to "pretty strong"

But there's another element of the Johnson & Johnson vaccine that is particularly compelling: It involves only one dose. The Pfizer and Moderna vaccines are both administered in two-dose regimens. Novavax's (NASDAQ:NVAX) close-to-market candidate is also a two-dose shot. That means Johnson & Johnson produced these decent results with only one jab. So, instead of saying the results are "decent," we might want to say they're pretty strong.

What's so great about a one-dose vaccine? For those of us holding out an arm, it means one uncomfortable jab instead of two. Most people would appreciate that. And it's even better for governments and hospital systems. Vaccine supply and distribution have been a problem. Many people who've received one dose of vaccine worry more doses won't arrive in due time for the second shot. With a one-dose vaccine, more people can be fully vaccinated with a given supply of product. And of course, storage and transportation become easier to tackle too...

Johnson & Johnson applied for Emergency Use Authorization (EUA) on Feb. 4. The company said it will be ready to distribute doses immediately following a possible EUA. If the company's timeline is anything like that of Pfizer and Moderna, its vaccine may be on the market as early as March.

A look into the future

Right now, the world needs more doses than Pfizer, Moderna, and Johnson & Johnson could produce. So all three can thrive in this market. But down the road, once the pandemic is over, Johnson & Johnson's one-dose vaccine could gain in market share -- and even become the market leader...

Source: Adria Cimino, Excerpt from Johnson & Johnson's Vaccine Is Less Effective Than Rivals. Here's Why It Could Still Win Big, The Motley Fool, February 6, 2021.

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Last Updated : Sunday, June 13, 2021