The antiviral pill, tecovirimat, also known as Tpoxx, has never been tested in humans with smallpox because the disease was declared eradicated in 1980, three years after the last known case.
But it was very effective at protecting animals deliberately infected with monkeypox and rabbitpox, two related diseases that can be lethal. It also caused no severe side effects when safety-tested in 359 healthy human volunteers, the F.D.A. said.
Tecovirimat (also known as TPOXX or ST-246) is FDA-approved for the treatment of human smallpox disease caused by Variola virus in adults and children. However, its use for other orthopoxvirus infections, including monkeypox, is not approved by the FDA.
Tecovirimat showed protective efficacy against lethal challenge with every orthopoxvirus tested, in multiple animal models.
Tecovirimat, a little-known antiviral, shows promise against monkeypox. But human data and supplies of the drug are limited.
The antiviral Tecovirimat (TPOXX) shows promise against monkeypox, but human data and supplies are limited.
The government's strategic national stockpile holds 1.7 million TPOXX courses. So far, 10,000 courses have been sent to states and cities on request – but "the number of [courses] deployed does not necessarily equate the number of [courses] administered," a spokesperson from the Department of Health and Human Services wrote in an email to NPR.
Virus has taken hold amid ragged system ravaged by years of underfunding, messy bureaucracy and Covid.
The markets may be in free fall, but a few biotechnology companies had an exceptionally good day. Siga’s stock is up more than 40%; Emergent Biosolutions’s gained nearly 12%, and Tonix Pharmaceuticals, 15%. Outside the US, Danish company Bavarian Nordic jumped 19%.
The reason? They make treatments for monkeypox.
A smallpox antiviral that’s effective against monkeypox is tied up in red tape, and gay-health advocates are pushing to make it easier to access
Clinicians and healthcare facility pharmacists can request TPOXX preferably by contacting their state or territorial health department; however, they can also reach out directly to CDC by contacting its Emergency Operations Center (EOC, 770-488-7100; [email protected]).
Currently, most people with monkeypox have no access to this drug, and few providers are even aware it is available. Members of the gay community have been messaging each other to try to find it and are growing increasingly angry that they cannot access the one drug that could ease the suffering of people with monkeypox, not to mention their limited access to testing or vaccines.
It is recommended that patients 13 kg and above initiate oral treatment with TPOXX capsules if possible. If patients are unable to take oral TPOXX capsules or Drug-Food Preparation, treatment may be initiated with TPOXX injection...