Lynch Syndrome

A half-century ago, when researchers said cancers were caused by exposure to toxins in the environment, Dr. Henry T. Lynch begged to differ. Many cancers, he said, were hereditary - Gina Kolata

Lynch Syndrome
Lynch Syndrome

image by: Lynch Syndrome International

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Message from the founder

My genes don’t define me. I am AliveAndKickn. Pretty bold statement. AliveAndKickn is more than just a name. It’s a way of life. I joke that Lynch syndrome is the genetic predisposition to colon cancer, endometrial cancer, other cancers…and soccer. But that’s just me. Besides half a dozen surgeries since 1997, I have and still play the game I love. You may find your own game, or hobby, or solace in something that can help you in your day.

Lynch Syndrome, other hereditary cancers, even other disorders are difficult to absorb and overcome. We’re here for you. We are looking to make a difference for you and others, both current and future with hereditary cancer. Part of that is helping…

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  Message from the founder

Genetics is taking huge strides almost every day. Precision medicine, immunotherapy and gene sequencing are the future. We thank you for being a part of our lives. I’m humbled to be part of yours. Be resilient.


To improve the lives of individuals and families affected by Lynch syndrome and associated cancers through research, education and screening.

HEROIC Registry for Lynch Syndrome

The HEROIC Registry is a patient-centric genetic database that will enable patients to take an active role in furthering research into Lynch syndrome genetic mutations. The HEROIC Registry allows patients to contribute medical information and their experiences living with Lynch syndrome and its associated cancers to help researchers develop new treatments...

Lynch Syndrome Intl

Lynch Syndrome Intl (LSI) is dedicated towards raising awareness, providing education to the public and doctors & promoting research.

Colon Cancer Alliance for Research and Education for Lynch Syndrome

Educate the public and healthcare professionals about Lynch Syndrome and to help fund research for a cure for this disease.

Myriad Genetics

About three to five percent of colon or rectal cancers (colorectal cancers) are believed to be caused by mutations in the MLH1, MSH2, MSH6, PMS2 and EPCAM genes.

People who have Lynch syndrome have a significantly increased risk of developing colorectal cancer. There is also an increased risk of developing other types of cancers, such as endometrial (uterine), stomach, breast, ovarian, small bowel (intestinal), pancreatic, prostate, urinary tract, liver, kidney, and bile duct cancers. Lynch syndrome is among the most common hereditary cancer syndromes, and estimates suggest as many as 1 in every 300 people may be carriers of an alteration in a gene associated with Lynch syndrome. Clues to whether there is Lynch syndrome in a family include diagnoses of colorectal and/or endometrial cancer in multiple relatives on the same side of a family.


People with Lynch syndrome are more likely to get colorectal cancer and other cancers, and at a younger age (before 50)...

Macmillan Cancer Support

Lynch syndrome (LS) is a condition that can run in families. LS is also known as hereditary non-polyposis colorectal cancer (HNPCC). It is caused by an alteration in a gene called a mismatch repair gene. LS doesn’t cause any symptoms. But people with LS have an increased risk of developing bowel cancer, womb cancer and some other cancers. If your family has a history of developing these cancers when they are under 50 years old, it is possible they have the altered gene that causes LS.


Identifying patients with Lynch syndrome is clinically important because these patients have up to 80 percent lifetime risk of colorectal cancer and up to 60 percent lifetime risk of endometrial cancer.

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