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Rybelsus: A New Era in Type 2 Diabetes Management

Rybelsus, the brand name for semaglutide, represents a relatively novel advancement in the oral management of type 2 diabetes mellitus (T2DM). Traditionally, the treatment landscape for T2DM has been dominated by injectable therapies, particularly for those requiring glucagon-like peptide-1 receptor agonists (GLP-1 RAs). Notably, semaglutide’s development as an oral formulation marks a significant shift, aiming to improve patient compliance and broaden therapeutic access.

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How Effective is Rybelsus for Weight Loss?

Is Rybelsus a weight loss drug? No, Rybelsus is not a weight loss medication. This prescription drug is not approved by the U.S. Food and Drug Administration (FDA) for chronic weight management in obese or overweight individuals. However, taking Rybelsus to control blood glucose levels may help you lose weight. This medication comes in tablet form and is taken by mouth once daily in the morning on an empty stomach.

Oral Semaglutide (Rybelsus) for the Treatment of Type 2 Diabetes Mellitus

Oral semaglutide may be considered as an option for patients who need better glycemic control and are unable or reluctant to start or add injectable treatment and for whom weight loss is desired. It does not increase major CV events (including nonfatal stroke or nonfatal myocardial infarction) in higher-risk patients. The cost and hyperglycemia-lowering benefits of oral semaglutide are similar to those of injectable semaglutide; however, it is much more expensive than other oral agents.

Rybelsus for Weight Loss: Everything You Need to Know

Colloquially, people refer to Rybelsus as “the pill form of Ozempic.” That’s because it’s taken orally, and it has the same active ingredient (semaglutide).

Rybelsus Is Ozempic in a Pill — Is It Just as Good?

Rybelsus is the only approved oral form of semaglutide. It’s a daily pill, and it has been shown to result in clinically significant weight loss and blood sugar improvements, both alone and in combination with other diabetes drugs.

Rybelsus Vs. Ozempic: Similarities and How the Drugs Differ, According to Endocrinologists

“Ozempic is one of the strongest medications for diabetes and weight loss that we have ever had in the history of medicine,” says Akhil Shenoy, M.D., endocrinologist and medical advisor at Aeroflow Diabetes. “Rybelsus is weaker and has similar efficacy to other oral anti-diabetes medications (very generally speaking).”

Semaglutide pill Rybelsus matches heart benefits of injectable versions

Novo Nordisk’s (NOVOb.CO), opens new tab diabetes medicine Rybelsus, an oral form of the GLP-1 drug semaglutide, provides similar cardiovascular benefits as the injectable forms of the drug, researchers reported at the American College of Cardiology scientific meeting in Chicago.

Wegovy Maker Novo Nordisk Says New Pill Shows 14% Reduction in Heart Attacks, Strokes in Diabetic Patients

Rybelsus is an oral form of semaglutide, the active ingredient in the company’s blockbuster Ozempic and Wegovy diabetes and weight-loss drugs, and was tested in the trial on diabetic patients who also suffered from established cardiovascular disease and/or chronic kidney disease.

What They Didn’t Tell You About Rybelsus

You trusted the information provided by the company, but they didn't tell you that semaglutide, the active ingredient, can increase your chances of developing a "paralyzed stomach" or gastroparesis. If you or a loved one has been feeling very sick with stomach problems, it could be because the full side effects of Rybelsus were not disclosed.

What to Know About Eli Lilly’s Daily Pill for Weight Loss

Another GLP-1 pill, Rybelsus, is made by Novo Nordisk and approved to treat only diabetes. It is the same drug as Wegovy and Ozempic but formulated as a pill, and results in modest weight loss. Because most of it is broken down in the stomach, the drug has to be taken in large doses. It is not as effective as the injectable drugs, making it much less popular.

Resources

Rybelsus

RYBELSUS® (semaglutide) tablets 7 mg or 14 mg is a prescription medicine used along with diet and exercise to improve blood sugar (glucose) in adults with type 2 diabetes.