The typical ED starting
dose seems to be 0.4 mg administered intravenously. Use of
this dose, like all things in medicine, is well supported by
multiple, large, randomized trials. Just kidding! It comes
from the 1960s anesthesia literature as the dose needed to
reverse excessive postoperative sedation in opioid-naive
patients.3 Decades later, changes in our patient population
and the opioids they use have complicated naloxone dosing.
Since people can already order fentanyl and other harmful drugs via the darknet, NEXT wants to make obtaining items that reduce harm just as easy to get.
Naloxone is an extraordinary, lifesaving medication. But at high doses, it can backfire.
Some drug users say that as long as the lifesaving drug is around, they don’t worry as much about dying.
The overdose-reversing drug naloxone saves thousands of lives each year and is more widely available today than ever. So why do overdose deaths across the U.S. continue to rise?
According to one 2018 study, naloxone itself is partly to blame. Naloxone, the authors of the study wrote, increases opioid use and does not reduce opioid-related mortality overall because it provides users with a “safety net” and thus encourages riskier drug use.
The drug that reverses opioid overdoses is safe and easy to use.
Think of them as an essential harm-reduction tool, like condoms.
You can learn how to administer naloxone yourself.
However, the most recent available data suggest that relatively few communities with high rates of opioid-related deaths actually have such programs.
Even emergency medical personnel, or EMS, may not have naloxone when they need it.
And although many emergency-service staff carry naloxone, they often arrive too late to save a life, not least because witnesses can be hesitant to call 911 for fear of police involvement. Getting naloxone into more people’s hands would not solve America’s opioid crisis, but it would save lives.
The effects of naloxone last for about 30 to 90 minutes, which is usually enough to stave off an overdose that could turn deadly. That not only can save a person’s life, but it also extends the opportunity to link someone to addiction treatment, such as highly effective medications like buprenorphine and methadone that are shown in the longer term to cut all-cause mortality among opioid addiction patients by half or more.
The study linked expanded access to naloxone to fewer opioid overdose deaths.
Once the exclusive purview of paramedics and emergency room doctors, administering lifesaving medication to drug users in the throes of an overdose is quickly becoming an everyday part of police work amid a national epidemic of heroin and opioid pill abuse.
A new paper suggests the overdose-reversing drug naloxone presents a “moral hazard.” The economists’ case is built on an immoral premise.
VICE News went to Massachusetts to see how effective Narcan has been in stopping fatal overdoses, and uncovered the reasons why other states may have been slow to adopt similar life-saving programs.
But three years after Evzio came out, its cost has exploded to $4,500 per prescription. Like the pharma company Mylan did with Epi-Pen—another simple, life-saving drug—Evzio's maker has raised its price as high as the market will bear.
For people who do want treatment, however, the good news is that three FDA-approved medications exist to treat opioid addiction. Together, the three are often termed “medication-assisted treatment,” or MAT.
The program was created with the idea that anyone, including minors, could walk into a participating pharmacy and leave with the drug, under what is known as a standing order: Pharmacists were to use the city health commissioner’s name, Mary T. Bassett, in place of a prescribing physician’s. They were to show the customer how to administer naloxone and bill their insurance.
Narcan is a fine place to start, but it’s not a solution. Opioids can inhibit the body’s response to the accumulation of carbon dioxide, suppressing our incentive to keep breathing, and Narcan works to reverse the drugs' effects. The treatment started as an injection used in clinical settings, but now friends or family members can use it as a nasal spray or a simple, EpiPen-like injection.
A paper on overdose-reversal drugs reached a conclusion no one liked. The pushback raised questions about sexism and scientific methods.
Naloxone can be a “moral hazard,” a new paper concludes.
Acute opioid intoxication and overdose are common causes of presentation to emergency departments. Although naloxone, a pure opioid antagonist, has been available for many years, there is still confusion over the appropriate dose and route of administration.
The primary goal of giving someone naloxone is not to revive them, but to restore their ability to breathe, since opioid overdoses kill people through asphyxiation, says Dr. Lewis Nelson, chair in the department of emergency medicine at Rutgers New Jersey Medical School.
As recreational drugs like cocaine are increasingly cut with fentanyl, a movement has sprung up to prevent deaths in nightclubs.
Are we enabling users and their friends/families to use heroin without fear of the repercussions that accompany it?
An online and mail-based harm reduction platform designed to reduce opioid overdose death, prevent injection-related disease transmission, and improve the lives of people who use drugs.
Do more than worry, when someone you love takes opioids, let NARCAN® be there for both of you.
The Law Enforcement Naloxone Toolkit provides law enforcement with the knowledge and tools needed to reduce opioid overdoses and help save lives.