Factor Xa inhibitors - the XaBans

It’s just another “me too” drug trying to shoehorn its way into the massive warfarin-replacement market - Ryan Radecki

Factor Xa inhibitors - the XaBans
Factor Xa inhibitors - the XaBans

image by: Julie Dalcourt

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The New Anticoagulants

The “xabans” are newly available oral agents; both rivaroxaban and apixaban have been approved by the FDA since 2010. Because their onset of action is rapid (peaks in 2-4 hours), parenteral bridging is often unnecessary. While anticoagulant effect is predictable and monitoring of anticoagulation is not required, a special assay is available if it becomes necessary to monitor the activity of the agent.

Rivaroxaban is approved for surgical DVT prophylaxis, stroke prevention in nonvalvular atrial fibrillation and treatment of DVT and PE. To date, apixaban is only approved for stroke prevention in valvular atrial fibrillation.

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 The New Anticoagulants

Rivaroxaban is approved for surgical DVT prophylaxis, stroke prevention in nonvalvular atrial fibrillation and treatment of DVT and PE. To date, apixaban is only approved for stroke prevention in valvular atrial fibrillation.

Andexxa

Andexxa is the first and only specific reversal agent for apixaban or rivaroxaban treated patients with life-threatening or uncontrolled bleeding

Arixtra (Fondaparinux)

ARIXTRA (fondaparinux sodium injection, USP) is a sterile solution containing fondaparinux sodium. It is a synthetic and specific inhibitor of activated Factor X (Xa).

Eliquis (ApiXaBAN)

ELIQUIS (apixaban) is a prescription medicine used to reduce the risk of stroke and blood clots in people who have atrial fibrillation (AFib), a type of irregular heartbeat, not caused by a heart valve problem.

Savaysa (EdoXaBAN}

SAVAYSA is a prescription medicine used to reduce the risk of stroke and blood clots in people who have atrial fibrillation (AFib) not caused by a heart valve problem. Based on how well your kidneys work, SAVAYSA may not be a treatment option for you. Your doctor should check your kidney function before starting treatment.

Xarelto (RiveroXaBAN}

XARELTO® is a prescription anticoagulant, or blood-thinning medication, proven to: •reduce the risk of stroke in people with Atrial Fibrillation (AFib), an irregular heartbeat, not caused by a heart valve problem •treat and help prevent deep vein thrombosis (DVT) and pulmonary embolism (PE), blood clots in deep veins (such as the legs) and in the lungs •reduce the risk of blood clots following hip or knee replacement surgery.

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