IT IS very rare for new evidence to question or even negate the utility of a well-established class of drugs. But after four decades as a standard therapy for heart disease and high blood pressure, it looks like this fate will befall beta blockers. Two major studies published within about a week of each other suggest that the drugs do not work for these conditions. This is a big surprise, with big implications.
The first beta blocker, Inderal, was launched in 1964 by Imperial Chemical Industries for treatment of angina. This drug has been hailed as one of great medical advances of the 20th century. Its inventor, James Black, was awarded the Nobel prize in medicine in 1988.
The usual initial dosage of metoprolol tartrate tablets is 100 mg daily in single or divided doses, whether used alone or added to a diuretic.
The usual initial dosage is 40 mg propranolol hydrochloride twice daily, whether used alone or added to a diuretic.
So what about mixed beta/alpha blockers like labetalol and carvedilol? Based on the evidence examined in both systematic reviews, there were no cases of bona-fide or even putative “unopposed alpha-stimulation” events. Labetalol was effective at treating concomitant tachycardia and hypertension.
More than a third of American adults use medications that list depression as a risk, and a quarter use drugs that increase the risk of suicide.
The common medication has been around since the 1960s but has evolved.
But maybe that modern world can help. I see nothing wrong with doing all we can to rid ourselves of pathological anxiety, including using drugs to alter our painful emotional memories.
Bananas have similar affects to a (pharmaceutical) drug class called beta-adrenergic blockers. Beta blockers are prescribed to treat anxiety, reduce blood pressure, or heart conditions. Beta blockers prevent adrenaline from binding to beta receptors which results in lower blood pressure and pulse rate, which normally skyrocket when experiencing anxiety and under stress.
Bananas have been shown to result similarly, acting as an all natural beta blocker in your body.
Beta-blockers still has important role to play in the modern approach to antihypertensive treatment now often based on the drug combinations.
The cheap and popular heart drugs known as beta-blockers may be overused in many patients, exposing them needlessly to bothersome side effects, a new study suggests.
Then they took over my life.
Although beta-blockers lower blood pressure in most patients, the outcomes of clinical hypertension trials of these drugs have been disappointing, and the value of beta-blockers in treating hypertensive patients who do not have compelling indications for them has been questioned. Until these drugs are proved beneficial, they should be used as antihypertensive therapy only in patients with compelling cardiac indications for them or as add-on agents in those with uncontrolled or resistant hypertension.
Amid growing expectations and pressures, some musicians are turning to medications to calm their nerves, but in the School of Music, the topic remains taboo.
Beta-blockers, used primarily as a treatment for heart disease, may help calm the nerves of anxious orators.
You see, nerves are okay. They’re manageable. They’re a useful signal. If you rely on medication you are saying your nerves are out of your control, treating your body as the enemy and the signals as a demon to be exorcized.
Propranolol, a beta-blocker that cuts heart rate, could silence the disastrous events on repeat in the minds of millions of people with PTSD.
With the release today of updated European and US guidelines the ongoing controversy regarding beta-blockers appears to be resolved. But that doesn't necessarily mean there will be an outbreak of guideline peace and harmony. The critics who helped ignite the controversy over beta blockers now say new statin recommendations contained in the guidelines are based on deeply flawed evidence.
Beta blockers have been around since the 1960s, but it took a while before anyone noticed how useful they were for performance anxiety. Probably the first performers to start using them widely were musicians, especially classical musicians, whose hands can get clammy or tremble during a concert performance.
Beta blockers work by blocking the effect of adrenaline and slowing the heart rate; they’re one of the most prescribed medications in the United States.
Despite a lack of recent studies, various surveys over the last three decades have estimated that 20 percent to 30 percent of symphony musicians regularly use beta blockers to quell their nerves.
Your grandpa takes beta-blockers for his heart, but could they help treat anxiety?
Beta-blockers are the fifth most commonly prescribed medication in US and are frequently involved in potentially fatal single or multi-drug ingestions. Cardiovascular drugs as a whole are the 2nd most common culprit of adult death from all overdoses.
The beta blocker drug list is extensive making it challenging to remember the mechanism of action and pharmacology of each one.
Some beta blocker medications are selective for beta 1 receptors, while other beta blockers are non-selective for beta 1 and beta 2 receptors.
A third category also antagonizes both alpha and beta receptors.
The release of the first beta blocker in the early 1960s revolutionized the treatment of chest pain caused by exertion or stress (angina). Over the following four decades, these old dogs have learned many new tricks, from protecting the heart after a heart attack to controlling heart failure.
They have treated heart disease for 40 years, but it now seems that beta blockers don’t work. What went wrong?
For the record, I’m not necessarily against the use of beta-blockers.
I just don’t think you need them.
In fact, if your goal is to play your absolute best, beta-blockers will probably hold you back.
•most ingestions are benign
•exceptions are those in the elderly those with decreased cardiorespiratory reserve, and those with coingestions of other cardiovascularly active agents
•two beta-blockers require special consideration:
— propanolol -> causes sodium channel blockade -> QRS widening -> treat with NaHCO3
— sotalol -> causes potassium efflux blockade -> long QT -> monitor for Torsades
Beta-blockers, also known as beta-adrenoceptor blocking agents, are medications used to treat conditions such as angina, heart failure and high blood pressure.
You cannot take a beta-blocker if you have certain conditions, including:
•Uncontrolled heart failure.
•Very slow heart (bradycardia).
•Low blood pressure (hypotension).
•Certain problems with the rhythm of your heart - eg, sick sinus syndrome.