Dual Receptor Blockers
Based on indirect comparison with other classes of drugs, the blood pressure lowering effect of dual alpha- and beta-receptor blockers is less than non-selective, beta1 selective and partial agonist beta blockers, as well as thiazides and drugs inhibiting the renin angiotensin system - Cochrane
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Labetalol and other agents that block both alpha* and beta-adrenergic receptors
The bulk of the therapeutic information about this family of agents comes from the study of labetalol, which has been marketed in Europe since 1975 and in the United States since 1982. Labetalol is effective in treating mild, moderate, and severe hypertension," and the parenteral form is useful when blood pressure needs to be lowered rapidly, as in accelerated or malignant hypertension.
Resources
Labetalol
DOSAGE MUST BE INDIVIDUALIZED. The recommended initial dosage is 100 mg twice daily whether used alone or added to a diuretic regimen. After 2 or 3 days, using standing blood pressure as an indicator, dosage may be titrated in increments of 100 mg b.i.d. every 2 or 3 days. The usual maintenance dosage of labetalol HCl is between 200 and 400 mg twice daily.
Carvedilol
The recommended starting dose of carvedilol is 6.25 mg twice daily.
Labetalol or Nifedipine for Acute Elevated BP in Pregnancy?
Oral nifedipine may be a better alternative due to its ease of oral administration and a flat dosing regimen.
Labetalol Hydrochloride Injection
Labetalol hydrochloride is an adrenergic receptor blocking agent that has both selective alpha1- and nonselective beta-adrenergic receptor blocking actions in a single substance.
NifeDipine or Labetalol for treating existing high blood pressure during pregnancy (the PANDA study)
Tommy’s is supporting an early trial into finding the best way to treat pregnant women with high blood pressure without harming mother or baby.
Labetalol and other agents that block both alpha* and beta-adrenergic receptors
The bulk of the therapeutic information about this family of agents comes from the study of labetalol, which has been marketed in Europe since 1975 and in the United States since 1982. Labetalol is effective in treating mild, moderate, and severe hypertension," and the parenteral form is useful when blood pressure needs to be lowered rapidly, as in accelerated or malignant hypertension.
7 things you should know
Labetalol tablets are usually given at a dosage of 100mg twice a day. The dosage is slowly increased as needed until an optimum effect on blood pressure is achieved; this maintenance dosage may differ from person-to-person.
Cochrane
Based on indirect comparison with other classes of drugs, the blood pressure lowering effect of dual alpha- and beta-receptor blockers is less than non-selective, beta1 selective and partial agonist beta blockers, as well as thiazides and drugs inhibiting the renin angiotensin system.
ScienceDirect
Intravenous labetalol, an agent that combines alpha- and beta-blocking properties, has proved to be the most useful agent in the treatment of hypertensive crisis.
StatPearls
Labetalol is one of the most commonly used anti-hypertensives medications used for the treatment of hypertension during pregnancy. Hypertension during pregnancy is an increasingly common and a leading cause of maternal mortality and morbidity worldwide.
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