Hydralazine (Apresoline)

Its use is best avoided in the management of hypertensive crises - Ashley and Brooke Barlow PharmDs

Hydralazine (Apresoline)

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Hydralazine is Broken (No Need to Fix It)

Hydralazine is much like rolling the dice on blood pressure management. You do not know when the blood pressure will change or what level to expect it to drop. Following its administration, hydralazine has a latent period ranging from five to 15 minutes before onset of action, and after onset it can cause an abrupt fall in blood pressure lasting up to 12 hours...

Perhaps the perception is that hydralazine is a benign medication and that one dose of hydralazine can't possibly be that harmful. Sadly, given its long half-life, adverse effects may not be recognized or connected to hydralazine if they occur hours later, prompting the clinician to make poor reactionary decisions.

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Last Updated : Friday, April 1, 2022