As a starter pretty much all diuresis is conducted by convincing the kidney to lose more Na. Lose the Na and the water will follow.
Ever since antiquity, we've used diuretics to pee more. Some diuretics like caffeine are ubiquitous (think tea or soft drinks). However, it wasn't until the twentieth century that mankind realized the pharmacological potential of diuretics. In 1937, researchers discovered carbonic anhydrase diuretics. By 1957, researchers had discovered much more potent chlorothiazide diuretics.
Often called water pills, these drugs help lower blood pressure and are a mainstay for treating heart failure.
Loop diuretics, more commonly known as water pills, are the most widely prescribed heart failure medications, but few studies had extensively compared their effectiveness until researchers examined three approved loop diuretics and found that even though one of them might offer more benefit, it is rarely prescribed.
The connection between diuretics and dieting is twofold. First, many of the conditions that are treated by administration of prescription diuretics—particularly hypertension, CHF, and idiopathic intracranial hypertension—are more common in obese patients, more difficult to treat in the obese population, or both. Thus weight loss and lifestyle change are commonly recommended to these patients along with prescription diuretics.
The second connection is that many dieters use or abuse diuretics as a means to quick weight loss.
The latest hypertension guidelines have underscored the importance of diuretics for all patients, but particularly for those with salt-sensitive and resistant hypertension.
Diuretics, or "water pills," are the oldest of the pharmaceuticals used for treating high blood pressure, and many doctors still consider them the safest and most reliable. The most common of these are the thiazide diuretics, with Hydrochlorothiazide being so widely prescribed that it is generally just referred to as HCTZ.
However, there is one class of prescription drugs that has largely escaped critical analysis on the Internet: diuretics. That is about to change. This article makes the case against diuretics and why you should think twice about taking them.
Early scientific studies have shown that many of these alternatives help the body excrete excess fluid.
Water pills are not new drugs, having been around for more than 50 years. The early diuretics replaced a brutal way to eliminate excess fluid through the use of tubes that were placed below the skin of swollen, edematous tissue to relieve the pressure.
You've probably heard the word "diuretic" thrown around in the context of coffee, tea, or certain medications. But what are diuretics, really? And are they a good thing—or a bad thing—for your health?
Door-to-diuretic time in this setting can’t be equated with door-to-balloon in STEMI, experts say. Better to “get it right” than “do it fast.”
You've probably come across commercials that promote water pills as a quick slim-down solution while channel surfing. Whether you want to de-bloat before a big night out, ditch the annoying PMS puffiness, or fit into your skinny jeans once and for all, word is they'll help you shed pounds in no time flat—but do they really work? And more importantly, are they safe?
This chapter explores how to achieve large-volume diuresis, while limiting iatrogenic complications.
Our experts weigh in on these widely used medications.
One such drug class can solve uncontrolled hypertension in perhaps half of cases yet is widely under-prescribed and/or under-dosed, with tragic consequences. It is not receiving the attention or use it merits and needs.
Acetazolamide is a diuretic and carbonic anhydrase inhibitor medication that is used to treat several illnesses. FDA-approved indications include glaucoma, idiopathic intracranial hypertension, congestive heart failure, altitude sickness, periodic paralysis, and epilepsy.
Furosemide is the most well known and widely used of the loop diuretics which include bumetanide, torsemide, and ethacrynic acid.
Increases the osmolarity of the glomerular filtrate -> increasing urinary volume.
The recommended initial daily dose is 25 to 100 mg of ALDACTONE administered in either single or divided doses is recommended. Dosage can be titrated at two-week intervals. Doses greater than 100 mg/day generally do not provide additional reductions in blood pressure.
Very few agents used for the treatment of any disease can boast such staying power, which is a testament both to the efficacy and safety of these compounds and to the relevance of salt and volume control in the management of essential hypertension - Marvin Moser MD
Not everyone can take diuretics. Diuretics can make some existing conditions worse, so it’s important to tell your doctor about any condition you have. You should also mention any medicine, herbal, vitamin or mineral supplements you’re currently taking.
Diuretics, also known as "water pills," are a common, inexpensive, and effective medication used to treat high blood pressure. They work by causing the kidneys to increase the amount of salt and water excreted from the body. This means you will urinate more than you usually do.