COX-2 Inhibitors

The controversy over the safety and effectiveness of Celebrex continues today - Katie Thomas

COX-2 Inhibitors

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Should you still take Celebrex?

While celecoxib may be appropriate for a small number of patients, our reservations about it remain strong. Here's why:

It's probably harder on the heart. Although the evidence is mixed, some meta-analyses, which assess the combined data from many clinical trials, have linked celecoxib at higher or more frequent doses to an increased likelihood of heart attack compared with either a placebo or naproxen. Indeed, the government's Agency for Healthcare Research and Quality now says that naproxen is less likely than other NSAIDs to harm the heart. And the AHA says celecoxib should be used to treat people at risk of heart attack only if other measures have failed. That…

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Last Updated : Wednesday, February 19, 2020