Successfully translating scientific discoveries requires a primal sense of urgency, which some disease foundations seem to have, and many big pharmas appear to need.
Scientists are called on to come up with answers under pressure whenever there is a crisis, from the Challenger space shuttle explosion to the 2020 California wildfires. As they shift from “regular” to “crisis” research, they must maintain rigorous standards despite long hours, mentally demanding tasks and persistent outside scrutiny. Thankfully, science produced under urgent conditions can be just as robust and safe as results produced under normal conditions.
As society and healthcare institutions tentatively seek to return to normality, we can see that this new way of working is fragile with forces pulling us back.
By strengthening current translational medicine (TM) practices and preparing for advances, organizations could enhance the power of TM and increase its influence on R&D productivity overall.
In order to cure specific diseases, the new paradigm is for researchers to focus almost exclusively on 'translational' studies directly related to diagnostics and treatment. But is this wise?
What's the best way of doing research? Throwing money at bright minds or trying to solve a particular problem? Or is there a third way?
Translational research focuses on taking the learnings, data and outcomes from academic projects and transforming them into actual interventions. In pharmaceutical R&D, it helps make a drug a reality.
Translational medicine is a process fundamental for the society as it aims at developing new interventions beneficial to the patients. However, translational medicine is at a historic moment of crisis. The process is becoming unsustainable in spite of enormous technological advances, since the technological explosion has not been accompanied by a reinforcement of quality in experimental designs, especially in the discovery phases. However, there is no clear path neither for clinicians nor for scientists regarding the process of how a discovery leads to an approved drug.
Following your gut takes on a whole new meaning as scientists find relationships between the brain and gut bacteria.
What is wrong is that translational research is being seen as a panacea that will address the flagging rate of new biomedical advances. The thinking seems to declare that if only more people were given more money and deliberately focused on direct application, we would suddenly see a windfall of new therapies against disease. This thinking suffers from two major problems.
The coronavirus disease 2019 (COVID-19) pandemic and resulting vaccines are a potent reminder of the definitive impact of biomedicine and the unique ability of a workforce steeped in both basic research and clinical medicine to respond to a medical crisis. However, the reminder arrives at a critical juncture, with fewer and fewer physicians trained in both biomedical research and clinical medicine.
Journal of Translational Medicine is an open access journal publishing articles focusing on information derived from human experimentation so as to optimise the communication between basic and clinical science.
Science Translational Medicine is the leading weekly online journal publishing translational research at the intersection of science, engineering and medicine. The goal of Science Translational Medicine is to promote human health by providing a forum for communicating the latest research advances from biomedical, translational, and clinical researchers from all established and emerging disciplines relevant to medicine.
Translational Medicine is innovation toward achieving the conversion of knowledge and research breakthroughs stemming from the bench into clinical practices with the ultimate goal of improving patient outcomes.
Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research...
Clinical and Translational Medicine is high-impact open access journal with aims at promoting and accelerating the translation of preclinical research to a clinical application.
International Journal of Translational Medicine is an international, peer-reviewed, open access journal on major advances in both experimental and clinical medicine, with a particular emphasis on translational research...
Translational Medicine graduate program blog from Queen's University.