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Proteomics Might Have Saved My Mother’s Life. And It May Yet Save Mine.

Proteomics, or the study of proteins, has long offered the ability to identify many biological processes. But until recently, the sheer number of proteins and the complexity of their interactions made screenings impractical, if not impossible. Now, with the advent of more powerful computers and a form of artificial intelligence called machine learning, medical experts are imagining a future where proteomics will realize its power to tell us, to an incredible degree, what’s transpiring inside our bodies.

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Featured

  Proteomics: Introduction

Proteomics, the study of the total protein complement of a genome, is essential if we are to fully exploit the knowledge acquired as a result of mapping the entire human genome. The key strength to proteomics is that a DNA sequence alone is enough to figure out complex biological systems present within living cells. Functional proteomics takes the field one step further, mapping the activity of these proteins as they respond to changes in their environment, in response to drug treatment or in a disease state. This will be a particular challenge with respect to protein kinases as they are expected to be present within the cell in very small amounts.

 This new tool will help upend everything we assumed about ancient gender roles

Proteomics, the study of proteins present in our genetic makeup, is a cheaper and easier method than using ancient DNA to determine sex. By examining proteins in organic artifacts like teeth and bones, scientists can now learn details of the DNA that created them—but without having to analyze any actual DNA that may have survived. Such techniques, called proteomics, have “the capacity to revolutionize archaeology,” says Marta Cintas‑Peña, an archaeologist at the University of Seville and the lead author of a new study that used proteomics to determine the sex of the woman in the tomb.

Articles of Interest

Beyond Genomics: The Next Frontier: Proteomics

Even before they finished decoding the human genome, scientists began the next and far more challenging step in explaining the molecular underpinnings of life. It’s called proteomics–the cataloging and analysis of every protein in the human body. Although proteins are the direct result of the instructions coded in our DNA, they are far more variegated and complex than DNA. They have to be.

A golden era for personalized medicine is approaching, but are we ready?

Biobanks use next-generation sequencers to perform the genetic sequences at high speed, while the latest proteomics platforms enable measurement of thousands different biomarkers from a very small amount of blood. The resulting genetic and biomarker profiles are curated and made accessible through platforms like a national library.

A.I. Predicts the Shape of Nearly Every Protein Known to Science

DeepMind has expanded its database of microscopic biological mechanisms, hoping to accelerate research into all living things.

How AI could help map the organized chaos in our cells

As artificial intelligence seeps into various areas of our society, it's rushing into others. One area it's making a big difference is protein science. We're talking the molecules that make our cells work. AI has hurtled the field forward by predicting what these molecular machines look like, which tells scientists how they do what they do — from processing our food to turning light into sugar. Now, scientists at Google DeepMind have taken their protein prediction model to the next level with the release of AlphaFold3. It's an AI program that can predict the unique shape of proteins, as well as almost any other type of molecule a protein attaches to in order to function.

How Proteins Helped Scientists Read Between the Lines of a 1630 Plague Death Registry

New tech reveals bacterial contamination, what scribes were eating and how many rats were around.

New analysis of ancient human protein could unlock secrets of evolution

The technique – known as proteomics – could bring new insights into the past two million years of humanity’s history

Nobel Prize in Chemistry Awarded to Trio Who Cracked the Code of Proteins

Google DeepMind’s John Jumper and Demis Hassabis share honor with David Baker for transforming ability to understand human biology.

Nobel Prize in Chemistry Awarded to Trio Who Cracked the Code of Proteins

Google DeepMind’s John Jumper and Demis Hassabis share honor with David Baker for transforming ability to understand human biology.

Shining a Light on the World of Tiny Proteins

From viruses to humans, life makes microproteins that have evaded discovery until now.

Understanding cancer through proteomics

Hypothesis: it is possible to develop better ways of dealing with cancer by better understanding the body's proteins and how they interact (proteomics).

What Is Proteomics?

Proteomics is the large-scale study of proteins, which is crucial for understanding cellular processes and disease mechanisms at cellular and systemic levels. By generating comprehensive protein datasets, scientists understand the ebb and flow of protein expression in a tissue, how it differs from cell to cell, and how these differences illustrate the inner workings of an organism.

‘Moms in Proteomics’ aims to bring together a community for supporting mothers in STEM

As a woman, mother and scientist, I find my definition of success is constantly shifting between professional and personal goals and achievements. I realized that to maintain this balance I needed an outlet for sharing ideas and accepting feedback, so I founded Moms in Proteomics. Moms in Proteomics recognizes and highlights the unique needs of mothers in science, technology, engineering and mathematics (STEM). Specifically, the scientific theme of proteomics, a field dedicated to the identification and monitoring of protein production under different conditions.

Resources

Journal of Proteome Research

Journal of Proteome Research reports on global protein analysis and function, including genomics, spatio-temporal proteomics, metabonomics and metabolomics, and clinical proteomics.

Molecular & Cellular Proteomics

Molecular & Cellular Proteomics (MCP) publishes papers based on original research that are judged, after editorial review, to make a substantial contribution to the understanding of any area of proteomics.

Moms in Proteomics

Moms in Proteomics supports and encourages an intentional focus on the inherently unique physical, emotional, and biological commitments of Mothers, and the ensuing balance required to excel within the diverse STEM fields encompassing Mass-Spectrometry-based proteomics.

Proteome Sciences

Proteome Sciences is an established leader in CRO outsourced services to quantitate proteins and peptides in complex solid and fluid biological samples.