Hematologic Emergencies

There is no caste in blood - Edwin Arnold

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Hematologic Emergencies

The development of hematologic emergencies related to the underlying disease or as a result of complications of therapy is common in hematology practice. These hematologic emergencies can occur as an initial presentation or in a patient with an established diagnosis and are encountered in all medical care settings, ranging from primary care to the emergency department and various subspecialty environments.

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Featured

A True Hematologic Emergency

Acute chest syndrome may ultimately be the result of sickling within the microvasculature leading to pulmonary infarction, pulmonary embolism, viral pneumonia, or bacterial pneumonia. Acute chest syndrome may develop during a vaso-occlusive pain crisis or as an isolated event. It is the leading cause of morbidity and mortality in patients with sickle cell disease, with early recognition and treatment of paramount importance. None of the hemoglobinopathies is as catastrophic as acute chest syndrome.

CRACKCast E122 – Disorders of Hemostasis

These blood disorders are numerous and this episode attempts to break their classification and approach down in a systematic manner.

Emergencies in Malignant Haematology for the Intensivist

An overview of emergencies that are commonly seen in malignant haematology, side effects of novel therapies, and complications of allogeneic haematologic stem cell transplant.

Haematological Emergencies

Almost all haematological malignancies are curable with modern treatments such as chemotherapy, radiotherapy, immunotherapy and bone marrow transplantation.

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Day 5- Hematologic Emergencies

Other Hematologic Emergencies (not discussed elsewhere) include…APML, Febrile Neutropenia, Tumour Lysis Syndrome.

EM Boards Survival Guide: Hematology/Oncology 1

This week’s Survival Guide brings you a difficult topic: hematology/oncology. Read on for key resources and commonly tested concepts.

How I treat hematologic emergencies in adults with acute leukemia

Such complications, discussed herein, include tumor lysis, hyperleukocytosis, cytarabine-induced cellebellar toxicity, acute promyelocytic leukemia differentiation syndrome, thrombohemorrhagic syndrome in acute promyelocytic leukemia, L-asparaginase-associated thrombosis, leukemic meningitis, neutropenic fever, neutropenic enterocolitis, and transfussion-associated GVH.

POTD: Supratherapeutic INR

Although slowly dying out in terms of popularity, some providers STILL put their patients on warfarin. One of the last conditions where warfarin is indicated over a DOAC is in the setting of a mechanical valve, which can be a clue into the patient’s past medical history if you see it on their medication list (or that their PCP is old school). And even this may change as data on DOAC’s continues to evolve. There are multiple reasons why warfarin is a very annoying drug to work with.