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Pediatric Dose Optimization for Seizures in EMS (PediDOSE)

Standardized, age-based dosing may be simpler, faster and more effective, without compromising safety. The overall objective of the Pediatric Dose Optimization for Seizures in EMS (Pedi DOSE) study is to measure the impact of standardized EMS midazolam dosing on seizure treatment effectiveness and safety. To achieve this objective, we will conduct a large EMS trial to implement standardized, age-based midazolam dosing for pediatric seizures in 20 EMS systems nationally. We believe that implementation will stop more seizures before children arrive at EDs without increasing respiratory failure rates. The first aim of this study is to compare the impact of standardized EMS midazolam dosing relative…

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 Emergency Seizure Care, PediDOSE and Exception from Informed Consent

What we know from the doses that are currently used is that most kids get underdosed. And what we know from the standardized doses that we plan to use at PediDOSE is that these doses are safe doses that have been used in pediatric emergency medicine and pediatric dentistry without any significant adverse events.

Articles of Interest

The PediDOSE Study

The Pediatric Dose Optimization for Seizures in EMS (PediDOSE) study is an emergency medicine study designed to evaluate if a standardized method for paramedics to administer seizure medication leads to timely delivery of the right dose. The purpose of this study is to simplify how paramedics give medication to seizing children to stop the seizure and to decrease the number of children still seizing when they arrive at a hospital emergency department.

Deviation From National Dosing Recommendations for Children Having Out-of-Hospital Emergencies

We identified variance in weight-based dosing from national guidelines for common pediatric medications in the prehospital setting, which may be attributable to protocol differences or dosing errors. Addressing these should be a target for future educational, quality improvement, and research activities.

PediDOSE: Pediatric Dose Optimization for Seizures in Emergency Medical Services Study

The purpose of this study is to simplify how paramedics give medication to seizing children to stop the seizure and to decrease the number of children still seizing when they arrive at the emergency department.