Normal Pressure Hydrocephalus

Billy Joel could really change the entire trajectory of the condition - Amanda Garzón, Hydrocephalus Association

Normal Pressure Hydrocephalus
Normal Pressure Hydrocephalus

image by: DrAsif Iqbal

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Normal Pressure Hydrocephalus (NPH) - a potentially reversible cause of cognitive decline

The classical triad characteristics of the NPH often quoted among neurologists can be summed as “the three W’s - wet, wacky, and wobbly.” Meaning: urinary incontinence, cognitive changes, and gait difficulties define the condition. However, these findings are notoriously nonspecific in the age group of patients typically presenting to neurologists with cognitive concerns, so progress for a universal set of criteria has been slow. As of right now, there are at least two sets of criteria; one is international, and one is Japanese...

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 Normal Pressure Hydrocephalus (NPH) - a potentially reversible cause of cognitive decline

Normal pressure hydrocephalus has a large prevalence. For example, in a US population-based study of a 2 in 1000 for those younger than 79 years, and up to almost 6 in 100 for those age 80 and above1. It’s also a controversial diagnosis among neurologists, since agreed-upon universal diagnostic criteria are difficult to come by, with diagnostic methods themselves varying from clinic to clinic. However, it’s worth addressing, since it represents a potentially reversible cause of dementia in some patients.

Hydrocephalus Association

What makes the diagnosis of normal pressure hydrocephalus (NPH) difficult is the fact that normal pressure hydrocephalus symptoms occur in other conditions that are common in an aging population, such as Parkinson’s disease (PD), osteoarthritis, peripheral neuropathy, and Alzheimer’s disease (AD).

Dr. Mark McLaughlin

Billy Joel’s decision to publicly share his diagnosis shines a light on a condition that is frequently underrecognized. When a beloved public figure faces a medical challenge, it often encourages people to seek out information and ask questions—especially if they or someone they love may be experiencing similar symptoms. Normal Pressure Hydrocephalus is a reminder that not all cognitive decline or balance issues in older adults are inevitable or untreatable. With increased awareness and timely evaluation, many patients can regain independence and improve their quality of life.

BrainFacts.org

Normal pressure hydrocephalus (NPH) is an abnormal buildup of cerebrospinal fluid (CSF) in the brain's ventricles, or cavities. It occurs if the normal flow of CSF throughout the brain and spinal cord is blocked in some way. This causes the ventricles to enlarge, putting pressure on the brain. Normal pressure hydrocephalus can occur in people of any age, but it is most common in the elderly. It may result from a subarachnoid hemorrhage, head trauma, infection, tumor, or complications of surgery. However, many people develop NPH even when none of these factors are present. In these cases the cause of the disorder is unknown.

Cureus

NPH can be idiopathic, where there is no identifiable etiology, or secondary. Secondary causes of NPH include subarachnoid hemorrhage, infection, head trauma, or tumor. The estimated incidence is 5.5 per 100,000. The prevalence is estimated to be 0.41-2.94% throughout five different studies on the prevalence of idiopathic NPH in elderly patients, from different countries.

International Parkinson and Movement Disorder Society

Although recently the entity of normal pressure hydrocephalus has been questioned, in everyday clinical practice it is evident that normal pressure hydrocephalus really exists. However, it is important to make a distinction between secondary cases (e.g. appearing after meningitis, subarachnoid hemorrhage or trauma) and “idiopathic” cases. Also, as the CSF pressure dynamics are abnormal (CSF pressure diagram during the day-night cycle), the term “chronic hydrocephalus of the elderly” which was proposed about 20 years ago could be a more accurate term.

StatPearls

Normal pressure hydrocephalus characteristically presents with progressive gait impairment, cognitive deficits, and urinary urgency and/or incontinence.

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