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The latest on glucosamine/chondroitin supplements

When it comes to health supplements, glucosamine and chondroitin are among the most popular. The cost of these and other non-vitamin supplements and herbal remedies is close to 21 billion dollars per year. So, you’d think they must be highly effective. And yet, that’s not so clear.

They are touted not only as arthritis pain relievers but also as treatments to prevent joint disease. Yet, a number of past studies have come to mixed conclusions — some small studies found that people felt better taking glucosamine and/or chondroitin, but at least as many have found no benefit. A 2010 analysis of multiple studies (called a meta-analysis) found that among more than 3,800 people with osteoarthritis…

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 Exercise May Help Knees More Than Glucosamine And Chondroitin

If you're among the estimated 27 million Americans who suffer from osteoarthritis of the knee or hip, then perhaps you've tried the nutritional supplements glucosamine and chondroitin. They've been marketed for joint health for about 20 years, and sales are still brisk. But do they help? Some horses might say yes. The supplements were first tried in horses, and there's some evidence that the supplements might improve joint function for them. Glucosamine and chondroitin are also marketed to dog owners. But what about us humans? Unfortunately, researchers say that for us the results just don't match the glowing testimonials.

 Health Benefits of Chondroitin

After two years of treatment, people who took chondroitin and/or glucosamine had no better outcomes than those who took either a placebo or Celebrex.

Articles of Interest

Chondroitin Eases the Pain of Knee Arthritis

Patients with osteoarthritis of the knee who were treated with high-quality, prescription-grade chondroitin got as much pain relief after six months as those treated with a nonsteroidal anti-inflammatory drug, a new clinical trial has found. They also showed similar improvements in function, such as the ability to walk distances and perform daily activities.

Chondroitin for osteoarthritis

The combination of some efficacy and low risk associated with chondroitin may explain its popularity among patients as an over-the-counter supplement.

Glucosamine and Chondroitin for Osteoarthritis

Glucosamine and chondroitin sulfate are natural substances found in and around the cells of cartilage. Glucosamine is an amino sugar that the body produces and distributes in cartilage and other connective tissue, and chondroitin sulfate is a complex carbohydrate that helps cartilage retain water. In the United States, glucosamine and chondroitin sulfate are sold as dietary supplements, which are regulated as foods rather than drugs.

Glucosamine, Chondroitin Sulfate, and the Two in Combination for Painful Knee Osteoarthritis

Glucosamine and chondroitin sulfate alone or in combination did not reduce pain effectively in the overall group of patients with osteoarthritis of the knee. Exploratory analyses suggest that the combination of glucosamine and chondroitin sulfate may be effective in the subgroup of patients with moderate-to-severe knee pain.