HWN Suggests

Myelitis features and outcomes in CNS demyelinating disorders: Comparison between multiple sclerosis, MOGAD, and AQP4-IgG-positive NMOSD

Inflammatory myelopathies can manifest with a combination of motor, sensory and autonomic dysfunction of variable severity. Depending on the underlying etiology, the episodes of myelitis can recur, often leading to irreversible spinal cord damage and major long-term disability. Three main demyelinating disorders of the central nervous system, namely multiple sclerosis (MS), aquaporin-4-IgG-positive neuromyelitis optica spectrum disorders (AQP4+NMOSD) and myelin oligodendrocyte glycoprotein-IgG associated disease (MOGAD), can induce spinal cord inflammation through different pathogenic mechanisms, resulting in a more or less profound disruption of spinal cord integrity. This ultimately translates…

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Articles of Interest

Demystifying the Causes and Management of Transverse Myelitis

If you or someone close to you is living with transverse myelitis, then you know how life-altering this neurological condition can be. It often results in sudden symptoms, such as muscle weakness, pain and bladder dysfunction. It has several possible causes. Some people recover from the symptoms and resulting complications of transverse myelitis, while others don’t.

Modern Look at Transverse Myelitis and Inflammatory Myelopathy

Transverse myelitis (TM) comprises a heterogeneous group of inflammatory disorders affecting the spinal cord, which can present with a wide range of motor, sensory, and autonomic dysfunction.1 Potential mechanisms encompass demyelinating, infectious/parainfectious, autoimmune, and cryptogenic disorders. This broad differential can overlap with noninflammatory myelopathies and can be very challenging for clinicians to navigate, causing delays in diagnosis or treatment.

What we know about the polio-like illness paralyzing children—and what we don’t

Viruses called non-polio enteroviruses are the lead suspects for causing AFM. Infections from those viral types are common, and usually just cause mild, cold-like symptoms. But monitoring specific viruses within that category over the past few years has shown that AFM crops up in the same places that the virus does—specifically, the EV-D68 virus.

Resources

McMaster

Myelitis is an inflammatory process involving the nervous tissue of the spinal cord. It is caused by the presence of microorganisms in the tissue. The most common causative factor is a viral infection, including infections caused by enteroviruses...

Radiopedia

Myelitis is a collective term simply referring to any inflammation of the spinal cord. It is a form of myelopathy.