Renal Tubular Acidosis
The RTA syndromes are characterized by a relatively normal GFR and a metabolic acidosis accompanied by hyperchloremia and a normal plasma anion gap - Juan Rodríguez Soriano
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Renal tubular acidosis: ‘RTA is no accident’
The term ‘renal tubular acidosis’ (RTA) might logically be applied to any form of renal disease causing systemic acidosis, since the renal tubule is the only part of the kidney involved in acid excretion. By convention, however, the term is not used for the acidosis of patients with end-stage renal disease (ESRD), although they are usually acidotic.
For patients who are acidotic from predominantly tubular disease, now known as RTA, Fuller Albright originally coined the portmanteau expression ‘renal acidosis resulting from tubular-insufficiency-without-glomerular-insufficiency’. Over the 60 years following his pioneering work, a jumble of different diseases have been described that…
Resources
Renal Tubular Acidosis and Management Strategies: A Narrative Review
Alkali therapy may be used to correct acidosis in patients with distal or proximal RTA. In patients with distal RTA, alkali therapy also corrects for hypokalemia. Alkali therapy with 1–2 mmol/kg/day NaHCO3 or KHCO3 is normally sufficient to equal daily acid production [5]; however, in patients with nephrolithiasis or nephrocalcinosis, the elevated Na+ load with NaHCO3 therapy may cause increased urine calcium excretion, which can precipitate kidney stone formation. In these patients, K-citrate administration is preferable; this will also increase urine citrate excretion and prevent recurrence of kidney stones. Patients with severe hypokalemia should also receive K+ replacement (i.e., with KCl or K-citrate) to prevent further lowering of serum K+ concentrations and symptomatic hypokalemia.
Renal Tubular Acidosis - A quick guide
It is the development of a metabolic acidosis due to a defect in the ability of the renal tubules to either reabsorb bicarbonate or increase hydrogen excretion in response to an acidemia. All RTAs are characterized by a non anion gap metabolic acidosis.
Approach to Renal Tubular Disorders
The renal tubule plays an important role in fluid and electrolyte homeostasis. Renal tubular disorders may affect multiple (e.g., Fanconi syndrome) or specific (e.g., nephrogenic diabetes insipidus, renal glucosuria) tubular functions. Most conditions are primary and monogenic but occasionally are secondary to other disorders (focal segmental glomerulosclerosis, cystinosis, Lowe syndrome)
Distal renal tubular acidosis and severe hypokalemia: a case report and review of the literature
Distal renal tubular acidosis is a relatively infrequent condition with complex pathophysiology that can present with life-threatening electrolyte abnormalities.
dRTA: How is it Treated?
Sodium bicarbonate plays an important role in the treatment of primary dRTA by helping to lower the acidity (pH) of the blood. As with any medication, you should not take sodium bicarbonate or other medications unless your healthcare provider recommends it. Sodium citrate can be used if sodium bicarbonate is not effective or not well tolerated. Potassium bicarbonate or potassium citrate can be used when potassium levels in the blood are low (hypokalemia), or in some people with high blood and urine levels of calcium (hypercalciuria) or calcium kidney stones.
Renal Tubular Acidosis and Uraemic Acidosis
poorly understood by many physicians. RTA is often detected incidentally through an abnormal blood workup, but some patients present with clinical features such as poor growth, dehydration, or altered mental state
Renal tubular acidosis with Kidney Boy, Joel Topf MD
Listeners will be familiar with the physiology, pathogenesis, clinical manifestations and treatment of renal tubular acidosis and non anion gap metabolic acidosis
Renal Tubular Acidosis: The Clinical Entity
The RTA syndromes are characterized by a relatively normal GFR and a metabolic acidosis accompanied by hyperchloremia and a normal plasma anion gap
Review of the Diagnostic Evaluation of Renal Tubular Acidosis
The term renal tubular acidosis (RTA) describes a group of uncommon kidney disorders characterized by defective acid-base regulation. Reaching the diagnosis of RTA is complex and often delayed, resulting in suboptimal treatment.
The renal tubular acidoses
Renal tubular acidosis (RTA) arises when the kidneys either fail to excrete sufficient acid, or are unable to conserve bicarbonate, with both circumstances leading to metabolic acidosis of varying severity with altered serum potassium.
Valeria Bandes – Renal Tubular Acidosis
For parents with children who don’t seem to respond to any treatment, the needle-in-a-haystack diagnosis may seem unattainable. That was the case for Valeria Galindo Bandes, a child from Mexico who began having issues in utero.
Renal tubular acidosis: ‘RTA is no accident’
The term ‘renal tubular acidosis’ (RTA) might logically be applied to any form of renal disease causing systemic acidosis, since the renal tubule is the only part of the kidney involved in acid excretion. By convention, however, the term is not used for the acidosis of patients with end-stage renal disease (ESRD),
Acidosis Tubular Renal
Comunidad en Facebook cuyo objetivo es mejorar la calidad de vida de quienes padecen Acidosis Tubular Renal en México favoreciendo la difusión de la enfermedad y el diagnóstico oportuno.
Fanconi Syndrome
Renal Fanconi syndrome refers to the generalised dysfunction of the proximal tubule. In its isolated form, renal Fanconi syndrome only affects the proximal tubule and not the other nephron segments.
Primary Distal Renal Tubular Acidosis
Primary distal renal tubular acidosis affects females and males in equal numbers. The exact number of people who have this disorder is unknown. Rare disorders like primary distal renal tubular acidosis often go misdiagnosed or undiagnosed, making it difficult to determine their true frequency in the general population.
EMed
Tubular but not glomerular damage Primary or Acquired (sickle cell disease, Sjögren’s syndrome, SLE, lithium). Type 1 distal RTA - defect in excretion H+, Type 2 proximal RTA - poor bicarbonate re-absorption, Type 4 aldosterone deficiency (apparent or real).
KidsHealth
There are a few different types of renal tubular acidosis, and each has its own cause. They’re named based on the part of the tubule that’s damaged...
National Institute of Diabetes and Digestive and Kidney Diseases
RTA is a rare disease that is often misdiagnosed or undiagnosed, making it difficult to determine the true frequency in the general population. Who is more likely to have RTA? You are more likely to have type 1 RTA if you inherit specific genes from your parents or if you have certain autoimmune diseases such as Sjögren’s syndrome or lupus
Patient
There are various disorders of tubular function, both generalised and specific. These disorders may be isolated defects, generalised tubular defects, as in Fanconi's syndrome, or associated with more generalised disease processes.
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