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Disorders of Red Blood Cells

RBC disorders can be divided into two categories, congenital and acquired disorders. Congenital disorders include membrane defects, thalassemia, hemoglobinopathies, and enzyme defects and aplasia. Acquired disorders include immune destruction, mechanical destruction, anemia of chronic disease, nutritional deficiencies (i.e., deficiency of B12, folate, iron), and aplasia. These disorders have different clinical features and mechanisms of disease, but all result in anemia.

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 Gene Editing for Inherited Red Blood Cell Diseases

Today gene therapy is a real therapeutic option to address inherited hematological diseases that could be beneficial for thousands of patients worldwide. Currently, gene therapy is used to treat different monogenic hematological pathologies, including several red blood cell diseases such as β-thalassemia, sickle cell disease and pyruvate kinase deficiency.

Articles of Interest

Hemoglobin Disorders

In people with hemoglobin disorders, red blood cells are fewer in number, less able to do their job, or both. The most common hemoglobin disorders are sickle cell disease and thalassemia. Some version of the genes that cause these diseases also protect against malaria—a deadly parasite carried by mosquitoes. Through natural selection, these gene variations have become very common in certain parts of the world.

A Break in the Mystery of Sudden Running Deaths

A handful of genes could explain why sickle cell trait leaves some athletes at risk, and others perfectly healthy.

Back To The Basics: Blood Disorders

Anemia is not a disease but rather a symptom of an underlying disease process. It is a condition in which a patient does not have enough red blood cells (low hematocrit) or when their red blood cells do not function properly. Signs and symptoms include weakness, shortness of breath, dizziness, fast or irregular heartbeat, headache, cold hands or feet, pale or yellow skin, restless leg syndrome, and/or chest pain.

Blood disorders that affect Red blood Cells

Amongst the other disorders are Sickle cell anemia, polycythemia vera and malaria.

Disease of Red Blood Cells

Anemia is a condition where the number of red blood cells is decreased. There are many types of anemia, with some having more serious outcomes than others.

Disorders of Red Blood Cells (Erythrocytes) | Anemia

Erythrocytes a.k.a. Red Blood Cells help us transport oxygen throughout the body. But what happens when they don’t work the way they should? Let’s find out.

How are hereditary red blood cell membrane disorders classified?

By hydration and membrane parameters....

Miscellaneous Red Cell Abnormalities

Adult human bone marrow synthesizes 4 X 1014 molecules of hemoglobin every second. Heme and globin chains (alpha and beta) in adults are manufactured in separate cell compartments—mitochondria and cytoplasm, respectively—and then combined in the cytoplasm in an amazingly accurate manner. Four major problems can manifest during this delicate process:

New interest group for red blood cell disorders

Sickle cell disease and thalassemia are congenital conditions frequently seen in Asia, the Middle East, the Mediterranean countries and Africa. The incidence is also expected to increase in Norway as the composition of the population changes. These diseases are associated with a shorter lifespan and lower quality of life, but early diagnosis and good follow-up can reduce morbidity and mortality.

Red blood cell disorders

Disorders of red blood cells may be due to reduced or excessive production in the bone marrow, premature cell destruction (haemolysis) or loss from the circulation. A precise diagnosis must be made from the blood count, blood film, biochemistry and/or bone marrow examination so that appropriate therapy can be instituted.

The Iron in Our Blood That Keeps and Kills Us

As elements go, iron is a fickle and mischievous companion. Essential to life, yet impulsive, promiscuous, and destructive when allowed to roam unescorted, it poses a tremendous engineering challenge to human tissues.

Types of blood disorder

Non-cancerous blood disorders include aplastic anaemia, sickle cell disease, thalassaemia and autoimmune diseases.

Resources

Basicmedical Key

Peripheral smears...

The Red Blood Cell Disorders Hub

The RBCD Hub is a space to connect about Sickle Cell Disease, Thalassemia, and other Hemoglobinopathies in Ontario. Red Blood Cell Disorders are genetic conditions which affect red blood cells. This means people are born with these disorders due to the genes passed down from their parents. Sickle Cell Disease and Thalassemia are two major groups of red blood disorders. There are also other rarer disorders, including Diamond Blackfan Anemia, hereditary spherocytosis, and many others.