HWN Suggests

Eosinophils from Physiology to Disease: A Comprehensive Review

Despite being the second least represented granulocyte subpopulation in the circulating blood, eosinophils are receiving a growing interest from the scientific community, due to their complex pathophysiological role in a broad range of local and systemic inflammatory diseases as well as in cancer and thrombosis. Eosinophils are crucial for the control of parasitic infections, but increasing evidence suggests that they are also involved in vital defensive tasks against bacterial and viral pathogens including HIV. On the other side of the coin, eosinophil potential to provide a strong defensive response against invading microbes through the release of a large array of compounds can prove toxic…

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Articles of Interest

EOS counts in health

Eosinophils are multifunctional leukocytes that can be both helpful and harmful, making their role difficult to determine. While eosinophil involvement in inflammatory disease is well-established, more is being understood about their role in health and how they can help guide diagnosis and treatment decisions.

Eosinophils, Poetry, and Distilling Out Truth

This cell only emerged from the cobwebs of my brain recently when discussing a drug rash that is peculiar (aren't they all?) with a dermatologist, and she asked in a fevered shout and with uncharacteristic passion, “But what is the eosinophil count?”

Eosinophils: The unsung heroes in cancer?

Eosinophils and their mediators have been canonically associated with a detrimental role in allergic diseases, but these cells can induce a protective immune response of the host against helminthes, viral and microbial pathogens.

EOS counts in disease

During immune responses mediated by Th2 cells and group 2 innate lymphoid cells (ILC2), eosinophils become activated and multiply. Th2 cells and ILC2 cells are major sources of interleukin (IL-5), the main cytokine responsible for maturation, activation, and survival of eosinophils. Eosinophils release cytokines and chemokines to target foreign antigens, promote inflammation, and damage surrounding structures...

Looking Beyond Seasonal Triggers: Could Eosinophils Be Driving Your Patients' Severe Asthma?

Beyond symptom control, untreated eosinophilic asthma can also lead to serious consequences, including airway smooth muscle contraction, airway hyperresponsiveness, and airway remodeling. In addition, eosinophilic inflammation can lead to progressive airway damage and poor control.

Resources

EOS Network

Our mission Is to ensure that every person with an Eosinophilic Gastrointestinal Disease receives a prompt accurate diagnosis, the right treatment for them, and support to live with their condition.

EosinoPhilosophy.com

At GSK, we believe eosinophils count for a lot. They play a role not only in disease, but also in health—and we are committed to better understanding their potential impact on patients’ lives.

American Partnership for Eosinophilic Disorders

To passionately embrace, support, and improve the lives of patients and families affected by eosinophil-associated diseases through education and awareness, research, support, and advocacy.

Cincinnati Center for Eosinophilic Disorders

If you or your child has an eosinophilic disorder, you already know how often these conditions can be misdiagnosed and / or misunderstood. Our center, the first of its kind in the United States, provides help for children and adults from a team of international leaders in diagnosing, treating and researching these rare disorders (eosinophilic esophagitis [EoE], eosinophilic gastritis [EoG], eosinophilic colitis [EoC], eosinophilic gastroenteritis [EGE], hypereosinophilic syndrome [HES]).

National Eosinophilia-Myalgia Syndrome Network

The National Eosinophilia-Myalgia Syndrome Network, Inc., is a non-profit (501 C-3) organization dedicated to helping EMS survivors and their families by offering educational information and peer support.