HWN Suggests

The Current Directions of Searching for Antiparasitic Drugs

Parasitic diseases are still a huge problem for mankind. They are becoming the main cause of chronic diseases in the world. Migration of the population, pollution of the natural environment, and climate changes cause the rapid spread of diseases. Additionally, a growing resistance of parasites to drugs is observed. Many research groups are looking for effective antiparasitic drugs with low side effects.

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Articles of Interest

Antiparasitic Drugs in the United States—Two Roads to High Prices

Some segments of the US antiparasitic drug market have been targeted by a pharmaceutical industry increasingly focused on financialization and short-term returns. This business model is troubling to healthcare providers because it seems that vulnerable patients have been disproportionately affected. The examples of albendazole and miltefosine highlight different but equally important ways in which the US drug development mechanism has failed patients.

Antiparasitic Therapy

Despite a relatively narrow therapeutic pipeline for new antiparasitic drugs, there have been significant improvements in the treatment of these widespread infections...

Drug Therapy for Common Parasitic Infections Within the United States

This article will address drug therapy (and sometimes prevention) for the parasitic infections most relevant to pharmacy practice in the United States.

How to Cure The Diseases That Nobel-Winning Drugs Cannot

The avermectins that Campbell and Ōmura discovered, and especially their most potent member ivermectin, can control the symptoms of these diseases by killing the larval nematodes. But they aren’t cures, because they don’t damage the astonishingly sturdy adults. And since these worms can live for a decade, and can release thousands of new larvae every day, their hosts must resign themselves to years of regular treatments.

Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations

Today, ivermectin remains a relatively unknown drug, although few, if any, other drugs can rival ivermectin for its beneficial impact on human health and welfare. Ivermectin is a broad-spectrum anti-parasitic agent, primarily deployed to combat parasitic worms in veterinary and human medicine. This unprecedented compound has mainly been used in humans as an oral medication for treating filarial diseases but is also effective against other worm-related infections and diseases, plus several parasite-induced epidermal parasitic skin diseases, as well as insect infestations.

Resources

DrugBank.com

Drugs used to treat or prevent parasitic infections.

StatPearls

Antiparasitic drugs are a group of medications used in the management and treatment of infections by parasites, including protozoa, helminths, and ectoparasites.