A disease spread by sandflies seen as an exotic nuisance in the U.S. might not be solely a traveler’s disease after all. A new study published Wednesday in JAMA Dermatology suggests that most American cases of leishmaniasis are actually spread by native bugs, not caught while traveling. And thanks to climate change, the parasitic illness may become even more common in the years to come.
A new approach to the treatment of cutaneous leishmaniasis with magnetic nanobeads is showing promise.
Leishmania transmission during blood transfusion has been a major concern in endemic areas. Although carriers may not exhibit clinical evidence of the disease, the parasite can become active and multiply in the mononuclear phagocytic system in response to factors such as patient immunological and nutritional status.
While the disease is not fatal, it causes gruesome, lifelong scarring that can disfigure faces and limbs. Because it is not deadly, and because its victims are normally the rural poor, the disease is also neglected.
Scientists have discovered how a parasite responsible for spreading a serious tropical disease protects itself from starvation once inside its human host. The findings provide a new understanding of the metabolism of the Leishmania parasite and this new knowledge could potentially be used in its eradication.
However, there is one little nasty buggy and the troubling disease it transmits that is endemic in both Afghanistan and Iraq and that has bested the US military – the sandfly Phlebotomus and the protozoan parasite Leishmania. This disgraceful couple have been around for millennia; it’s thought that the biblical plague of boils described in Exodus 9:9, the “breaking out in sores on man and beast throughout the land of Egypt”, was in fact an epidemic of cutaneous leishmaniasis.
Impavido, made by Canada's Paladin Labs Inc, is an oral medicine approved to treat the three main types of leishmaniasis: visceral, which affects internal organs; cutaneous, which affects the skin; and mucosal, which affects the nose and throat.
This is the first drug approved by the FDA to treat cutaneous or mucosal leishmaniasis.
Whatever you do, do NOT do an image search for "cutaneous Leishmania".
Leishmaniasis is one of the most neglected tropical diseases with current high worldwide incidence. Caused by a group of protozoan parasites belonging to the genus Leishmania, an infection of the disease usually results with a variety of clinical syndromes, and can lead to death.
One of the least known consequences of modern conflict in the Middle East and East Africa has been the widespread devastation that results from a tropical infection known as leishmaniasis.
One of the least known consequences of modern conflict in the Middle East and East Africa has been the widespread devastation that results from a tropical infection known as leishmaniasis. The international scientific and diplomatic communities now have an opportunity to work together to prevent the spread of this neglected tropical disease and to develop new treatments or vaccines.
You may not have heard of NTDs because they've after all been neglected...by the media and many governments, funding agencies, businesses, etc. In other words, if major infectious diseases around the world were to have a party (which would be a horrible party to attend), NTDs would be the wallflowers in the corner, overlooked by many policymakers, scientists and funders.
A parasitic infection that's rare in the United States now appears to be showing up more often in American travelers, thanks in part to the growing trend of ecotourism, experts say.
Few who went looking for the lost city in the Honduran jungle returned intact. Nancy Rommelmann reviews “The Lost City of the Monkey God: A True Story” by Douglas Preston.
At the start of the 20th century it was renamed after Sir William Leishman, a British Army doctor serving in India, who first identified the parasite causing the visceral form of the disease. Dr. Leishman himself called the illness “dum dum fever” after the village where the soldier he cared for had been posted.
Like malaria, leishmaniasis is caused by a parasite that is carried by an insect – in this case, a female sandfly. After malaria it ranks as the second most deadly protozoan disease in humans. But, unlike mosquitoes that give just one form of malaria, the sandfly can give four forms of leishmaniasis. These forms range from lesions on the skin to infection of internal organs such as the spleen and liver. Lesions can lead to disability and disfiguring scars – and stigma. The other infections can be lethal if left untreated.
Leishmaniasis was first identified in the 1900s.
To work for the research of Leishmaniasis in all respects in India.
To coordinate research amongst people by developing indigenous methods for
carrying out diagnosis and treatment for Indian public...
LeishPathNet is part of the Global Challenges Research Fund (GCRF) funded by the Medical Research Council, Arts and Humanities Research Council, Biotechnology and Biological Sciences Research Council, Economic and Social Research Council and Natural Environment Research Council.
VL is characterised by prolonged fever, enlarged spleen and liver, substantial weight loss, and progressive anemia. These symptoms occur progressively over a period of weeks or even months. Coinfection with other infectious diseases is an increasing concern: HIV-VL coinfection has been reported in 35 countries worldwide. Almost all clinically symptomatic patients die within months if untreated.
I aim, in this blog, to dispel some myths about leishmaniasis. I also hope it of use to anyone who has recently been diagnosed with the disease and would like some idea of what to expect. I have not written at length about the disease itself as this information is available from much more respectable sources.
Leishmaniasis is a poverty-related disease with two main clinical forms: visceral leishmaniasis and cutaneous leishmaniasis. An estimated 0·7–1 million new cases of leishmaniasis per year are reported from nearly 100 endemic countries. The number of reported visceral leishmaniasis cases has decreased substantially in the past decade as a result of better access to diagnosis and treatment...
Leishmaniasis is a parasitic disease that is found in parts of the tropics, subtropics, and southern Europe. It is classified as a Neglected Tropical Disease (NTD). Leishmaniasis is caused by infection with Leishmania parasites, which are spread by the bite of phlebotomine sand flies. There are several different forms of leishmaniasis in people. The most common forms are cutaneous leishmaniasis, which causes skin sores, and visceral leishmaniasis, which affects several internal organs (usually spleen, liver, and bone marrow).
Leishmaniasis exists in many temperate and tropical countries of the world. The disease is most common in India, Bangladesh, Nepal, Sudan, Ethiopia, Afghanistan, Algeria, Iran, Saudi Arabia, Syria, Brazil, Colombia, Peru, and Bolivia.
The most common type of leishmaniasis is cutaneous leishmaniasis.
Leishmaniasis is found in parts of about 88 countries. Most of these countries are in the tropics and subtropics. It is possible but very unlikely that you would get this disease in the United States. But you should be aware of it if you are traveling to the Middle East or parts of Central America, South America, Asia, Africa or southern Europe.
Treatment is with medicines that contain antimony, a type of metal, or with strong antibiotics. The best way to prevent the disease is to protect yourself from sand fly bites.
More than 12 million people in 88 countries are known to be infected but many cases are asymptomatic. Furthermore, reporting is far from complete in many areas and true numbers are almost certainly very much higher.
The male to female ratio is about 2:1, probably due to greater exposure of women to places where there is a risk of sandfly bites.
The Leishmaniases are diseases caused by protozoan parasites from more than 20 Leishmania species that are transmitted to humans by the bites of infected female phlebotomine sandflies.
There are three main forms of the disease: cutaneous, visceral and mucocutaneous: cutaneous leishmaniasis, visceral leishmaniasis or kala-azar, and mucocutaneous leishmaniasis.