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  Treatment

Doxycycline 100 mg orally 2 times/day for 21 days.

 Lymphogranuloma Venereum – LGV – A Chronic Long-term STD

The likelihood of LGV infection following an exposure is unknown, but it is considered less infectious than some other STI/STDs. Lymphogranuloma venereum is more common in people with penises.

 Proctocolitis caused by lymphogranuloma venereum

The infection has historically been associated with painful inguinal lymphadenopathy (buboes) as its pathognomonic sign; however, in recent years, increasing attention has been given to rectal presentations of lymphogranuloma venereum.

Articles of Interest

Approach to lymphogranuloma venereum

Lymphogranuloma venereum has not historically been identified in Western countries. However, since 2003—when clinicians identified a cluster of such infections in the Netherlands—LGV has become endemic in Canada, the United States (US), the United Kingdom (UK), and Australia.

Lymphogranuloma Venereum (LGV) - What is that?

What to know about LGV and what to do if you have it.

Lymphogranuloma venereum, a rare disease in Canada and BC

At present, diagnosis is clinical. MSM with inguinal buboes or hemorrhagic proctitis should be treated as LGV on the basis of those symptoms. Serology can be done but it is not highly specific.

Lymphogranuloma Venereum: An Increasingly Common Anorectal Infection Among Men...

Recent published data from the United Kingdom suggest that a 7-day regimen of doxycycline, versus the currently recommended 21-day course, is effective in treating rectal LGV in most MSM.

Resources

Talk About It Dallas

LGV is not very common in the United States and is most often seen in individuals who have had unprotected receptive anal sex.

The BodyPro

LGV can be difficult to diagnose. Typically, the primary lesion produced by LGV is a small genital or rectal lesion, which can ulcerate at the site of transmission after an incubation period of 3-30 days. These ulcers may remain undetected within the urethra, vagina, or rectum. As with other STDs that cause ulcers, LGV may facilitate transmission and acquisition of HIV.

StatPearls

Lymphogranuloma venereum is common in the tropical and subtropical regions around the world. It is rare in the United States.[6] Lymphogranuloma venereum may occur at any age; however, the highest incidence of LGV is in the sexually active population between 15 and 40 years. Lymphogranuloma venereum probably affects both sexes equally although it is more commonly reported in men because early manifestations of LGV are more apparent in men.

Together We Can

Nearly all LGV infections seen in the UK in recent years have been in the rectum.