Active Tuberculosis Infection

Easy to catch but hard to diagnose, TB is almost as deadly today as it was 150 years ago. Better, cheaper drugs are a priority - Tedros Adhanom Ghebreyesus

Active Tuberculosis Infection

HWN Suggests

Why is the world losing the fight against history's most lethal disease?

TB is a disease of the vulnerable, which may be why so little has been done to modernise the fight against it. It spreads most easily in conditions of poverty, with people crowded together in poorly ventilated places. It is symptomatic of a failure to ensure everyone has access to healthcare and is free from poverty and poor hygiene. These are society’s failures, but the stigma often falls on individuals. Society tends to shun TB patients and the medical establishment subordinates their individuality to the demands of fighting the disease. Moreover, the costs of treatment can be catastrophic, driving families further into poverty. It is time to step up the effort. That requires better-targeted…

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Articles of Interest

A New Dose of Hope in the Battle With Tuberculosis

The FDA’s approval of a new therapy for drug-resistant strains of the disease shows the potential of public-private partnerships.

How to Get TB Patients to Take Their Pills? Persistent Texting and a ‘Winners Circle’

The drug regimens can be grueling, and patients often quit taking their medications. But turning it into a cellphone competition helps.

Management of active tuberculosis

The management of active TB-HIV co-infection involves prompt initiation of an appropriate multidrug TB regimen that is guided by DST, commencing cART and treatment monitoring.

Mind the gap – Managing tuberculosis across the disease spectrum

We currently have a binomial approach to managing tuberculosis. Those with active disease, ideally confirmed microbiologically, are treated with a standard 6-month, multi-drug regimen and those with latent infection and no evidence of disease with shorter, one or two drug regimens. Clinicians frequently encounter patients that fall between these two management pathways with some but not all features of disease and this will occur more often with the increasing emphasis on chest X-ray-based systematic screening. The view of tuberculosis as a spectrum of disease states is being increasingly recognised and is leading to new diagnostic approaches for early disease.

Treatment for Extreme Drug-Resistant Tuberculosis Wins U.S. Government Approval

The three-drug regimen cures 90 percent of people who have the deadliest form of the disease.

Treatment of active tuberculosis in special populations

The management of tuberculosis (TB) in people with medical co-morbidities, substance-use disorders, advanced age or pregnancy is challenging...

Tuberculosis: Current Treatments and Investigational Therapies

Goals for the treatment of active TB include curing the patient and minimizing the infection of others.9 The management of active TB requires a minimum of two drugs, and often three or four, used in combination for >6 months.10 Directly observed therapy (DOT) by a healthcare professional is a standard of care, as compliance with treatment is essential to eradicating infection.

Resources

StatPearls

Active tuberculosis is a condition in which Mycobacterium tuberculosis causes infection; typically in the lungs, although many systems can be involved. The World Health Organization estimates that, annually, around 8 million people develop active tuberculosis globally, and nearly 2 million people die from the disease. Of every 10 people infected with M. tuberculosis, one may develop an active infection sometime in their lifetime. After infection, the risk of developing active tuberculosis is highest in the first year, but the active disease usually occurs many years later in most patients

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