Clinical Trials
It's very, very rare that you announce results at lunchtime, and it becomes policy and practice by tea time, and probably starts to save lives by the weekend - Martin Landray
image by: MinhChau Da
HWN Suggests
RECOVERY 1 year on: a rare success in the COVID-19 clinical trial landscape
On 23 March, the UK National Health Service’s RECOVERY trial marked its first anniversary. Initially set up to test four possible treatment options in a few thousand hospitalized COVID-19 patients, the platform trial is still going strong. It has now enrolled nearly 40,000 patients — just under 10% of the UK’s hospitalized COVID-19 patient population — into 13 treatment arms.
In a landscape marked by poorly designed and underpowered trials, RECOVERY stands out as a rare bright spot. Its results have demonstrated the benefits of the steroid dexamethasone and the IL-6-targeting antibody tocilizumab, while showing the lack of efficacy for azithromycin, colchicine, convalescent plasma,…
Featured
Principal
PRINCIPLE is a UK-wide clinical study from the University of Oxford to find COVID-19 treatments for recovery at home. We are looking for medicines that can help people with COVID-19 symptoms get better quickly and stop them needing to go to hospital.
RECOVERY
This international clinical trial aims to identify treatments that may be beneficial for people hospitalised with suspected or confirmed COVID-19
STOIC
Early administration of inhaled budesonide reduced the likelihood of needing urgent medical care and reduced time to recovery after early COVID-19.
Together
The TOGETHER Trial hopes to help identify which repurposed therapies are most effective, in order to slow the pandemic while many countries await the delivery of vaccines.
Everything you need to know about the COVID-19 therapy trials
There are thousands of clinical trials investigating treatments and preventative measures for COVID-19. Researchers around the world are working at record speed to find the best ways to treat and prevent COVID-19, from investigating the possibility of repurposing existing drugs to searching for novel therapies against the virus.
Articles of Interest
One U.K. trial is transforming COVID-19 treatment. Why haven't others delivered more results?
Clinical study has been helped by a simple design, a centralized health care system, and lots of infections
Results - Recovery Trial
The trial was up and running within six weeks of funding and found one of the world’s first COVID-19 treatments, dexamethasone. This cheap, readily available steroid was shown to reduce deaths of hospitalised COVID-19 patients by one third.
The COVID pandemic’s lingering impact on clinical trials
Medical researchers are beginning to shift their focus away from COVID-19 — but the pandemic could continue to affect studies focused on other diseases.
Resources
CenterWatch
A listing of COVID-19 medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
ClinicaTrials.gov
ClinicalTrials.gov is a resource provided by the U.S. National Library of Medicine.
MediData
COVID-19 and Clinical Trials: The Medidata Perspective
TrialSiteNews
TrialSiteNews was launched to drive more interest and awareness in clinical research, as well as to develop trust and facilitate engagement of researchers and the public. TrialSite started toward the end of 2018, financed solely by the founder, to create a new disruptive force in the world of biomedical research.
