Is ivermectin ready to be part of a public health policy for COVID-19 prophylaxis?

For Honduras, a low middle-income country, the proposal of a low-cost prophylactic agent for COVID-19 is appealing. In the face of a virus with a high mutation rate that could lead to loss of effectiveness of vaccines, worldwide research of therapies for COVID-19 such as ivermectin should not be idled.

  A COVID-19 prophylaxis?

It is important to note that the hypothesis that ivermectin might have a prophylactic effect against SARS-CoV-2 is merely based on a rather strong correlation. On the other hand, this correlation has grown increasingly stronger in the worldwide data set earlier this year and then been independently replicated within the African data set later in the summer. Both remain highly significant, suggesting that there may be a causal connection, which is also suggested by other recent findings reported in literature.

  I-MASK+ Prevention & Early Outpatient Treatment Protocol for COVID-19

The I-MASS protocol has been developed for Mass Distribution during regional outbreaks or in resource poor countries to lessen the impact and spread of COVID-19.

 A Prominent Study Said Ivermectin Prevents COVID, But The Data Is Suspect

An influential study from Argentina has been used to argue that ivermectin prevents COVID 100% of the time — but its inconsistencies have led experts to question if it could have actually happened as advertised.

 Covid-19: Why all the fuss about ivermectin, that became in many countries a ‘dirty word’

This article is not trying to answer this question but instead looking for readily available information because this drug has been the focus of much media attention recently.

 Use of ivermectin reduces risk of Covid disease

Using the drug ivermectin for prophylactic or preventive purposes among healthcare workers with high exposure to patients with the virus reduces the risk of presenting symptomatic Covid-19 by 74% compared to their peers working under the same conditions.

A Progressive Biologist From Portland Is One of the Nation’s Leading Advocates for Ivermectin

Because of people like Bret Weinstein, a drug meant for 1,000-pound animals is flying off the shelves in feed stores.

Censorship Kills: The Shunning of a COVID Therapeutic

Our manuscript conclusions were further supported by the British Ivermectin Recommendation Development (BIRD) Panel. Following the World Health Organization Handbook of Guideline Development, it voted to strongly recommend the use of ivermectin in the treatment and prevention of COVID-19, and opined that further placebo controlled trials are unlikely to be ethical.

Ivermectin against COVID-19: The unprecedented consequences in Latin America

In Brazil and in most of Latin American (LATAM) and Caribbean countries, IVM has been prescribed and widely used for the preventive treatment of the severe acute respiratory syndrome coronavirus (SARS-CoV-2) immediately after the publication of its in vitro effect against the virus

Ivermectin and COVID-19: How a Flawed Database Shaped the Pandemic Response of Several Latin-American Countries

The policy decisions of ivermectin in Latin-American have been largely based on the analysis presented in a pre-print...

Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review,...

Ivermectin is likely to be an equitable, acceptable, and feasible global intervention against COVID-19. Health professionals should strongly consider its use, in both treatment and prophylaxis.

Prophylactic Role of Ivermectin in Severe Acute Respiratory Syndrome Coronavirus 2 Infection Among Healthcare Workers

Two doses of oral ivermectin (300 μg/kg/dose given 72 hours apart) as chemoprophylaxis among HCWs reduced the risk of COVID-19 infection by 83% in the following month. Safe, effective, and low-cost chemoprophylaxis has relevance in the containment of pandemic alongside vaccine.

Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19

Based on the totality of the clinical and epidemiologic evidence presented in this review, and in the context of a worsening pandemic in parts of the globe where ivermectin is not widely used, the authors believe the recommendation must be immediately updated to support and guide the nation’s health care providers.

Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study

We conclude that two-dose ivermectin prophylaxis at a dose of 300 μg/kg body weight with a gap of 72 hours was associated with a 73% reduction of SARS-CoV-2 infection among HCWs in the following one month. Chemoprophylaxis has relevance in the containment of pandemic. This is an intervention worth replicating at other centers until a vaccine is widely available.

The BIRD Recommendation on the Use of Ivermectin for Covid-19

The British Ivermectin Recommendation Development panel recommends ivermectin for the prevention and treatment of covid-19 to reduce morbidity and mortality associated with covid-19 infection and to prevent covid19 infection among those at higher risk.

The Drug that Cracked COVID

Kory sometimes despairs at the forces against him. “Our little Ivermectin has so many big enemies,” he says. “It’s David versus ten Goliaths.” But word is getting out. More than twenty countries representing some 20 percent of the Earth’s population use Ivermectin, many in their national protocol. Every day it seems Kory hears from someone like the Toronto doctor, a Bulgarian, who used Kory’s data to convince the health ministers in his home country to sign on. Kory talks every day to his growing base of 17,000 Twitter followers, and his peer-reviewed paper on Ivermectin recently exploded online as one of the most-discussed scholarly papers ever posted out of seventeen million tracked by Altmetric.