Merkel Cell Carcinoma
Due to its rarity, there will likely never be a television advertisement for Merkel cell carcinoma - Gina Mauro
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image by: European Cancer Patient Coalition
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Merkel Cell Carcinoma: An Immunotherapy Fairy-Tale?
The history of Merkel cell carcinoma (MCC) therapy is studied with frustration and poor outcomes to treatments until the introduction of immunotherapy, which has radically changed the therapeutic paradigm of this disease…
The incidence of MCC is slowly but steadily growing worldwide. However, MCC is often misdiagnosed and part of this increase in incidence is probably due to the improvement of diagnostic skills, techniques, and the discovery of new biomarkers.
Resources
Merkel Cell Carcinoma: What To Know About The Skin Cancer That Killed Jimmy Buffett
Merkel cells are found in the topmost layer of the skin near nerve endings, and cancer forms when those cells grow out of control, often forming lumps in the areas most exposed to the sun, the National Cancer Institute says.
A dot on his skin became a life-threatening scare...
The outlook is beginning to change with the Federal Drug Administration's approval in 2017 of the first drug, Bavencio, for advanced Merkel cell.
Immunotherapy Drug as First-Line Therapy for Merkel Cell Carcinoma
The fact that the incidence is highest in people who are immunosuppressed provides some support for the idea that Merkel cell carcinoma is an immunogenic cancer, one that is related to immune function, and a good candidate for immunotherapy.
Living with Merkel Cell Carcinoma: A Survivor Insures His Own Future
Throughout his journey with Merkel cell carcinoma, Jepson certainly experienced moments of fear and doubt. But he met people along the way that kept him going as well.
Merkel Cell Carcinoma – Deadlier than Melanoma
You may have heard about the three most common types of skin cancer: basal cell carcinoma, squamous cell carcinoma, and melanoma. A lesser-known form of skin cancer called Merkel cell carcinoma has been steadily increasing in number over the last few decades. Since the 1990s, the number of diagnosed cases has increased by 5% to 10% per year.
Merkel Cell Carcinoma: An Update and Immunotherapy
Merkel cell carcinoma (MCC) is a rare but highly aggressive neuroendocrine skin cancer, which was described for the first time in 1972 as trabecular carcinoma of the skin.
Merkel Cell Carcinoma: From Pathobiology to Clinical Management
Merkel cell carcinoma (MCC) is an uncommon type of skin cancer that carries a poor prognosis. It is seen predominantly in old age in sun-exposed body parts. Racial and geographical differences are seen in its occurrence. Viral infection and radiation exposure are the two leading factors implicated in its causation.
Merkel Cell Carcinoma: Information for Patients & Treating Physicians
Rare (2,500 cases/year in US) and aggressive skin cancer that arises from uncontrolled growth of cells that share some characteristics with normal Merkel cells of the skin.
Merkel Cell Carcinoma: The Past, the Present, and the Future
Since the discovery of the Merkel cell in the skin in the 19th century and the description of the Merkel cell carcinoma in the early 70s, many new implementations in medicine with regard to diagnosis, imaging, and treatment have been introduced. However, the management of patients with Merkel cell carcinoma is a tremendous challenge for the clinician as well as the patient and their families.
Scratching Beneath the Surface in Merkel Cell Carcinoma
Due to its rarity, there will likely never be a television advertisement for Merkel cell carcinoma. Yet, several opportunities to help raise awareness and conduct an array of clinical trials are building, due to the disease’s response to checkpoint blockade.
Scratching Beneath the Surface in Merkel Cell Carcinoma
Due to its rarity, there will likely never be a television advertisement for Merkel cell carcinoma. Yet, several opportunities to help raise awareness and conduct an array of clinical trials are building, due to the disease’s response to checkpoint blockade.
Merkel Cell Carcinoma: An Immunotherapy Fairy-Tale?
The history of Merkel cell carcinoma (MCC) therapy is studied with frustration and poor outcomes to treatments until the introduction of immunotherapy, which has radically changed the therapeutic paradigm of this disease.
Merkel Cell Carcinoma Awareness Campaign
We want to raise awareness on this rare but extremely aggressive form of skin cancer known to have a 25 – 40% chance of recurring and spreading (metastasizing) in two to three years after first diagnosis. We encourage everyone to spread the information about the disease and to join the campaign on social media, re-sharing our posts or creating your own.
MerkelCell.org
On this website that we have maintained since 2004, we combine summaries of the best available literature and our experience caring for over 1,000 patients with MCC at the Seattle Cancer Care Alliance and the Dana-Farber Cancer Institute.
Cancer Treatment Centers of America
MCC originates from Merkel cells that have become cancerous. Merkel cells, which are skin cells that convey the sensation of touch, are located at the junction of two skin layers, the dermis and epidermis.
Skin Cancer Foundation
Merkel cell carcinoma (MCC) is a rare, aggressive form of skin cancer with a high risk for returning (recurring) and spreading (metastasizing), often within two to three years after initial diagnosis.
StatPearls
Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine tumor of the skin with increasing incidence. It most frequently presents on the head and neck region of elderly, white males.
YaleMerdicine
The cancer forms in special “Merkel” cells in the skin—a type of neuroendocrine cell that combines qualities from cells of both the nervous and endocrine systems. They’re located near the nerve endings within the skin, and, when functioning normally, help people recognize the sensation when something or someone touches their skin very gently. Merkel cell carcinoma develops when something causes these cells to grow uncontrollably.
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