Vascular Complications
Trying to manage diabetes is hard because if you don't, there are consequences you'll have to deal with later in life - Bryan Adams
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Microvascular and Macrovascular Complications of Diabetes
The importance of protecting the body from hyperglycemia cannot be overstated; the direct and indirect effects on the human vascular tree are the major source of morbidity and mortality in both type 1 and type 2 diabetes. Generally, the injurious effects of hyperglycemia are separated into macrovascular complications (coronary artery disease, peripheral arterial disease, and stroke) and microvascular complications (diabetic nephropathy, neuropathy and retinopathy).
Articles of Interest
The Link Between Diabetes and Vascular Disease
Some medical professionals refer to this condition as diabetic vascular disease because over time, chronic diabetes can permanently damage the blood vessels anywhere in the body, from the legs, to the kidneys to the eyes.
Common mechanisms underlying diabetic vascular complications: focus on the interaction of metabolic disorders, immuno-inflammation, and endothelial dysfunction
Diabetic vascular complications (DVCs), including macro- and micro- angiopathy, account for a high percentage of mortality in patients with diabetes mellitus (DM). Endothelial dysfunction is the initial and role step for the pathogenesis of DVCs. Hyperglycemia and lipid metabolism disorders contribute to endothelial dysfunction via direct injury of metabolism products, crosstalk between immunity and inflammation, as well as related interaction network.
Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I
Hyperglycemia and insulin resistance are key players in the development of atherosclerosis and its complications. A large body of evidence suggest that metabolic abnormalities cause overproduction of reactive oxygen species (ROS). In turn, ROS, via endothelial dysfunction and inflammation, play a major role in precipitating diabetic vascular disease.
Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part II
Diabetes and vascular disease are intimately linked and share pathophysiological features as examined in Part I of this review. In this section, we review the epidemiology and clinical consequences of vascular disease in patients with diabetes, and discuss the efficacy of risk factor modification and antiplatelet treatment.
The Impact of Diabetes on Vascular Disease: Progress from the Perspective of Epidemics and Treatments
Diabetes can cause vascular complications directly or indirectly through a variety of mechanisms. Vascular lesions caused by diabetes include macrovascular and microvascular lesions. Macrovascular lesions may lead to cerebrovascular disease, cardiovascular disease, and peripheral vascular disease. Microvascular diseases can cause specific complications, such as renal failure, retinopathy, and neuropathy. In recent decades, the global incidence of diabetes has been on the rise, and coupled with the growth of the population base, the number of people with diabetes has gradually increased.
Vascular complications of diabetes
Adults with diabetes have an annual mortality of about 5.4% (double the rate for non-diabetic adults), and their life expectancy is decreased on average by 5-10 years. Although the increased death rate is mainly due to cardiovascular disease, deaths from non-cardiovascular causes are also increased. A diagnosis of diabetes immediately increases the risk of developing various clinical complications that are largely irreversible and due to microvascular or macrovascular disease.
Vascular complications of diabetes: mechanisms of injury and protective factors
In patients with diabetes, atherosclerosis is the main reason for impaired life expectancy, and diabetic nephropathy and retinopathy are the largest contributors to end-stage renal disease and blindness, respectively. An improved therapeutic approach to combat diabetic vascular complications might include,,,
Resources
6 Diabetes Vascular Complications - And How To Avoid Them
People who live with diabetes know they have a lot of health management to do – monitor their blood sugar, stay alert for eye problems and monitor for foot infections. But some may not understand that many of the most common complications of diabetes stem from one primary issue: the havoc that high blood sugar, also called hyperglycemia, causes for the body's blood vessels. Because blood brings oxygen to every living cell in the body, when blood vessels aren't working properly, the body suffers.
