Alpha Glucosidase Inhibitors

There is no firm evidence that AGI have a beneficial effect on cardiovascular mortality or cardiovascular events - Cochrane.org

Alpha Glucosidase Inhibitors
Alpha Glucosidase Inhibitors

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Diabetes Medicine: Alpha-Glucosidase Inhibitors

Alpha-glucosidase inhibitors are a less popular class of medicines for type 2 diabetes. They work in your gastrointestinal tract to block your body’s ability to break down carbohydrate, thereby reducing the amount of glucose that enters the bloodstream.

You likely know that when you eat a food that contains carbohydrate, such as cereal or pasta, the carbohydrate in this food must be digested into glucose, which is then used to fuel the body. In order for this to happen, certain enzymes must kick in. These enzymes include alpha-amylase and alpha glucosidase. Alpha-glucosidase inhibitors block the action of these enzymes, reducing the rate of carb digestion and slowing the amount of…

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 Diabetes Medicine: Alpha-Glucosidase Inhibitors

There are so many types of diabetes medicines available that, chances are, you may not have heard about some of them. Alpha-glucosidase inhibitors are a less popular class of medicines for type 2 diabetes. They work in your gastrointestinal tract to block your body’s ability to break down carbohydrate, thereby reducing the amount of glucose that enters the bloodstream.

ScienceDirect

AGIs are saccharides that act as competitive inhibitors for the enzymes in the small intestine to slow down the digestion of carbohydrates such as starch, so that glucose from food enters the bloodstream more slowly, leading to the reduction in postprandial hyperglycaemia.

StatPearls

AGIs inhibit the absorption of carbohydrates from the small intestine. They competitively inhibit enzymes that convert complex non-absorbable carbohydrates into simple absorbable carbohydrates. These enzymes include glucoamylase, sucrase, maltase, and isomaltase. By delaying carbohydrate absorption, they reduce the rise in postprandial blood glucose concentrations by about 3 mmol/l. Acarbose is the most commonly used drug of this class.

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