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Type 1 diabetes research: poised for progress

Since type 1 diabetes was first proposed to be an autoimmune disease in the 1970s, the search has been on to identify the key pathogenic determinants and immune cell types involved. The Immunology of Diabetes Society Congress in October, 2018 (London, UK) featured a debate questioning the Achilles' heel of type 1 diabetes: is it regulatory T-cell dysfunction, misdirected cytotoxic T cells, autoimmune B cells, type 1 interferon, or a viral infection? The audience—comprising many of the world's leading experts on the disease—could not agree. After years of intensive research, including dozens of carefully designed clinical trials, how is it possible that the mystery underlying type 1 diabetes…

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Last Updated : Thursday, July 11, 2019