Epidiolex
The approval of Epidiolex "serves as a reminder that advancing sound development programs that properly evaluate active ingredients contained in marijuana can lead to important medical therapies - Sarah Jacoby
image by: Rebecca Bailey Roten
HWN Suggests
The first FDA-approved cannabis-derived drug is available for prescription in the US
Epidiolex contains cannabidiol—the chemical compound also known as CBD—which is increasingly popular for its reported abilities to deliver relief from maladies such as anxiety, joint pain, insomnia, and nausea. And while Epidiolex is approved specifically for treating two potentially fatal forms of severe childhood epilepsy, Lennox-Gastaut syndrome and Dravet syndrome, there’s a good chance it will be prescribed for “off-label” use.
“The off-label use of CBD and Epidiolex will be a fascinating subject to look at over the coming years,” Orrin Devinsky, the director of the Comprehensive Epilepsy Center at NYU Langone Health and the lead investigator of two clinical trials of Epidiolex,…
Resources
Can Medical Marijuana Control Seizures?
Epidiolex, a mostly purified plant-based cannabidiol oil, was approved by the US Food and Drug Administration (FDA) in 2018 to treat seizures in people with Dravet syndrome and Lennox-Gastaut syndrome, two rare forms of childhood-onset epilepsy. In 2020, Epidiolex was approved to treat seizures caused by tuberous sclerosis complex, a rare genetic disease that causes benign tumors to grow in the brain—which can lead to seizures—and other areas. The drug is a liquid that's administered orally with a special syringe.
How Can Whole-Plant CBD Oil and FDA-Approved Epidiolex Reduce Seizures?
Several key studies led to federal approval of Epidiolex as a legal, obtainable treatment option for people suffering from severe forms of epilepsy including Dravet syndrome and Lennox-Gastaut syndrome, both of which cause frequent and dramatic seizures in children. However, Epidiolex is just one potential cannabis-based treatment for epilepsy, and other studies have examined how whole-plant cannabidiol (CBD) oil may work better as the treatment does not trigger side effects that some patients have experienced with Epidiolex, such as diarrhea.
How Does Epidiolex Work? And How Does It Differ From Hemp Oil?
Overall, the FDA’s approval of Epidiolex is likely a good move for the cannabis industry as a whole. It helps the industry become more credible, sets higher quality expectations, proves that CBD has medicinal value, and will likely encourage further research on cannabinoids and their potential health benefits
How One Boy's Fight With Epilepsy Led To The First Marijuana-Derived Pharmaceutical
Scientific and public interest in CBD had been percolating for several years before the Food and Drug Administration finally approved Epidiolex in June. But CBD — which doesn't cause the mind-altering high that comes from THC, the primary psychoactive component of marijuana — was hard to study, because of tight restrictions on using cannabis in research.
More Evidence That Weed Extract Effectively Treats Epilepsy in Children
It's the first large randomized clinical trial of CBD to help treat seizures.
My 10-Year-Old Daughter Takes the First FDA-Approved Marijuana Drug. It's Changed Our Lives
It’s really impossible to tell which child it’s going to work for, but for us, it’s been great. I don’t want to say her seizures were eliminated, because we notice something occasionally, but sometimes we go weeks without seeing a seizure, and we haven’t seen any convulsions.
My Son Pioneered an Epilepsy Drug Derived From Marijuana. An FDA Panel Just Approved It
The treatment was fast-tracked for approval, and the first person to use the drug in the US was our writer's son.
This cannabis-derived drug just got approved, but that won’t make it easier to get edibles
Once again, the government says it’s okay to get cannabis from your doctor, but not over the counter.
What You Need to Know About Epidiolex, the First FDA-Approved Drug Made From Cannabis
The approval of Epidiolex "serves as a reminder that advancing sound development programs that properly evaluate active ingredients contained in marijuana can lead to important medical therapies.
The first FDA-approved cannabis-derived drug is available for prescription in the US
Although according the US Drug Enforcement Agency (DEA), marijuana is still a schedule I substance—meaning that it has no medical use and high potential for abuse—Epidiolex was classified as a low-restriction schedule V substance in September.
Epidiolex
EPIDIOLEX is a prescription medicine that is used to treat seizures associated with Lennox-Gastaut syndrome, Dravet syndrome, or tuberous sclerosis complex…
Dravet Syndrome News
Epidiolex is a plant-derived cannabidiol, a non-psychoactive marijuana extract. This means that it does not have the mind-altering effects that are characteristic of delta (9)-tetrahydrocannabinol (THC). Doctors have used marijuana derivatives to treat epilepsy since the late 19th century. However, researchers still do not fully understand how cannabidiol works to treat epilepsy. They suggest it may be through the treatment’s ability to interact with many other non-cannabinoid receptors in the brain.
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