Estrone (E1)
There is absolutely no evidence, no biochemistry or physiology textbook, and no scientifically sound study that states estrone is a dangerous molecule. So who declared it so? This “evil” concept is only found in articles quoting other articles or speakers quoting other speakers who are deficient in the knowledge of estrone physiology - Lisa Everett Andersen BSC
HWN Suggests
Is Estrone Evil?
Hmmm, not likely. If this is true, then the creation of our bodies included a huge mistake. Without estrone, we have no estrogen at all. Estrone is the first estrogen made in the human body. It is made from androstenedione (from either 17-OH progesterone or from DHEA). It can then be metabolized to estradiol, which, in turn, can be metabolized to estriol. In yet another act of contribution to estrogen balance, estrone is the storehouse for estradiol. Estrone is 10 times weaker than 17beta-estradiol. Additionally, testosterone can not be effective, even for boosting libido, without adequate levels of estrone and estradiol to prime the testosterone receptor sites. Yet, estrone has been falsely…
Articles of Interest
Estrone Test: High & Low Levels + Normal Range
Estrone (E1) stimulates the estrogen receptor about ten times more weakly than E2. Estrone is produced in the ovaries (similar to other estrogens) but also in fat tissue.
Estrone, the major postmenopausal estrogen, binds ERa to induce SNAI2, epithelial-to-mesenchymal transition, and ER+ breast cancer metastasis
Recent work showed that the dominant post-menopausal estrogen, estrone, cooperates with nuclear factor κB (NF-κB) to stimulate inflammation, while pre-menopausal 17β-estradiol opposes NF-κB. Here, we show that post-menopausal estrone, but not 17β-estradiol, activates epithelial-to-mesenchymal transition (EMT) genes to stimulate breast cancer metastasis.
The Good, The Bad and The Ugly!
E1 (estrone)- this is the main estrogen made in menopause... When E1 is metabolized in the body there are three main "estrones" it becomes. There is 2-hyroxyestrone (2-OH estrone), 4- hydroxyestrone (4-OH estrone) and a 16-hydroxyestrone (16-OH estrone). Not only are the levels of each important, but also their ratios.
Resources
Cleveland Clinic
After menopause, estrone is the only type of estrogen that your body keeps making naturally. Postmenopausal people usually have higher estrone levels than those who are premenopausal. Some conditions can cause high estrone. Because estrone forms in fatty tissue, obesity can lead to more estrone production.
Dr. George Arnold
Prior to menopause, estrone is made by the ovaries, adrenal glands, liver, and fat cells. Estrone converts to estradiol in the ovaries until post-menopause, at which time production occurs in a woman’s fat cells. That is unfortunate since weight gain is one symptom of menopause, and high levels of estrone can increase the risk for both breast and endometrial (uterine lining) cancer.
News Medical
After the reproductive age, when a woman has achieved menopause, estrone or E1 becomes that primary estrogen. Estrone is weaker than estradiol. It has been postulated that estrone is a “bad” estrogen and may be the cause of estrogen’s cancer-causing properties, while estriol is a “good” estrogen and may protect against cancer. Estradiol is probably neutral. There is no definite scientific evidence to prove this hypothesis however.
You and Your Hormones
Oestrone is a hormone produced by the ovaries, adrenal glands and fat. It is one of the major oestrogens in postmenopausal women.
