The widely accepted ‘anti-obesity limb’ of leptin physiology has never been clearly demonstrated to be present in human biology - Eleftheria Maratos-Flier


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Does the Emperor Have Clothes?

The hormone leptin—discovered 22 years ago and named based on the Greek word leptos, “slim”—has been widely hailed as the key regulator of leanness. Yet, the key experiments that probe the function of this protein and unravel the precise mechanism of its action as a guardian against obesity, are largely missing.

These are the conclusions in a commentary published June 22 in Cell Metabolism by Harvard Medical School metabolism experts Jeffrey Flier and Eleftheria Maratos-Flier. Flier, the HMS George Higginson Professor of Physiology and Medicine, and Maratos-Flier, HMS professor of medicine at Beth Israel Deaconess Medical Center, have made significant contributions to the understanding…

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 Does the Emperor Have Clothes?

Decades after the discovery of anti-obesity hormone, scant evidence that leptin keeps lean people lean, scientists say.

Leptin 101: How This ‘Hunger Hormone’ May Be Preventing You From Losing Weight

When a person is not in balance then their brain doesn’t sense leptin levels correctly, which builds up a resistance to the hormone. Almost all overweight people have HIGH leptin levels.

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