HWN Suggests

A thin layer of sucrose octasulfate protects the oesophageal mucosal epithelium in reflux oesophagitis

Sucralfate, a complex salt composed of aluminium hydroxide and sucrose octasulfate (SOS) polymer, is widely used to treat gastrointestinal diseases such as gastric and duodenal ulcers. Sucralfate is effective for the treatment of human reflux oesophagitis1,2,3,4; however, current first-line treatments for gastroesophageal reflux disease (GERD) are proton pump inhibitors (PPIs) which control gastric acid secretion. More recently, sucralfate or a combination of sucralfate and acid suppressor has offered new therapeutic regimens for patients with unsatisfactory responses to PPIs alone5; these are especially preferred by patients during pregnancy and lactation6,7.

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Articles of Interest

Can Sucralfate Be Used as an Adjunct Therapy for Treating GERD?

This case demonstrates how GERD adversely affects a patient’s QoL. Further, it elucidates that patients with GERD can be treated effectively by administering a combination of PPIs and sucralfate, a gastroprotective drug that helps mucosa regeneration by strengthening the mucosal barrier & heals mucosa.

Carafate tablets

CARAFATE contains the active ingredient sucralfate. It belongs to a group of medicines used to treat ulcers and gastro-oesophageal reflux disease.

CARAFATE- sucralfate suspension

The recommended adult oral dosage for duodenal ulcer is 1 gram (10 mL) four times per day. Sucralfate oral suspension should be administered on an empty stomach. Antacids may be prescribed as needed for relief of pain but should not be taken within one-half hour before or after sucralfate oral suspension.

History of the Development of Sucralfate

Sucralfate was introduced in Japan as a selective ulcer-protecting agent in 1968 and it is currently accepted worldwide as a nonsystemic site protector. This agent has an unusual developmental history among the drugs for peptic ulcer disease (PUD). The development of sucralfate is a true reflection of international collaboration.

Effect of sucralfate on gastroesophageal reflux in esophagitis

Twelve weeks of treatment with sucralfate in an open clinical trial resulted in a significant reduction of gastroesophageal reflux and the elimination of esophageal mucosal damage.

Sucralfate: 7 things you should know

Sucralfate contains aluminum. After oral administration, small amounts of aluminum are absorbed. This may lead to aluminum accumulation in people with poor kidney function or who are taking other aluminum-containing products (such as antacids).

The Use of Sucralfate Suspension in the Treatment of Oral and Genital Ulceration of Behçet Disease

Our results showed that topical sucralfate suspension is an easy, safe, inexpensive, and effective treatment for oral and genital ulceration in patients with Behçet disease.

What to know about Carafate for treating gastritis

A 2020 review suggests doctors may favor proton pump inhibitors (PPIs), such as omeprazole and cimetidine, for gastritis. However, the reviewers comment that they should consider sucralfate even ahead of suppressing acid, given the drugs’ favorable safety and toxicity profile and superior rates of gut healing.

Resources

Carafate (Sucralfate)

Carafate is an antiulcer drug that is used in the short-term treatment of active duodenal ulcer. It is also used in maintenance therapy for duodenal ulcer patients at a reduced dosage after healing acute ulcers. This drug works by forming a barrier or coating over the ulcer, protecting it from stomach acid and allowing it to heal. Side effects include drowsiness, convulsions, constipation, and backache.

PDR

Oral aluminum-containing sucrose sulfate complex; forms adherent, protective barrier at sites of damaged GI mucosa, shields mucosa from pepsin, acid, and bile; used for esophagitis, GERD, GI ulceration, and stomatitis.

StatPearls

Sucralfate is a medication used to treat duodenal ulcers, epithelial wounds, chemotherapy-induced mucositis, radiation proctitis, ulcers in Behcet disease, and burn wounds. Sucralfate exhibits its action by forming a protective layer, increasing bicarbonate production, exhibiting anti-peptic effects, promoting tissue growth, regeneration, and repair. The medication has a relatively safe profile as there is negligible absorption from the enteral system.