As a starter pretty much all diuresis is conducted by convincing the kidney to lose more Na. Lose the Na and the water will follow - Andy Neill
image by: ﺻﻴﺪﻟﻴﻪ ﺍﻟﻨﻮﺭ الطبيه
Furosemide was discovered in 1962. It is on the World Health Organization’s list of essential medications, the medications most important to a basic health system. Furosemide is also on the list of drugs banned in athletic competition, due to concerns that it may mask the presence of other performance-enhancing drugs. Furosemide’s brand name Lasix comes from the fact that the drug, when given orally, “lasts six” hours.
Furosemide, sold under the brand name Lasix, is a loop diuretic that blocks the sodium-potassium-chloride transporter in the ascending limb of the loop of Henle. This blockade results in decreased reabsorption of sodium, chloride, and water . Diuresis starts within 30 minutes of intravenous administration and peaks in 1 to 2 hours.
The usual total daily dosage of Bumex tablets is 0.5 mg to 2 mg and in most patients is given as a single dose.
The usual initial dose of LASIX is 20 mg to 80mg given as a single dose. Ordinarily a prompt diuresis ensues. If needed, the same dose can be administered 6 to 8 hours later or the dose may be increased. The dose may be raised by 20 mg or 40mg and given not sooner than 6 to 8 hours after the previous dose until the desired diuretic effect has been obtained.
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