Lisinopril
Captopril was the first ACE inhibitor developed and was considered a breakthrough both because of its novel mechanism of action and also because of the revolutionary development process - Ankala Subbarao
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From snake venom to ACE inhibitor — the discovery and rise of captopril
In the early 1980s, hypertension conferences were routinely enlivened by the poisonous Brazilian viper, Bothrops jararaca. With its striking zig-zag markings and aggressively protruding tongue, images of the snake were a welcome break from graphs and tables in presentations about captopril — the first of the angiotensin-converting enzyme (ACE) inhibitors, whose effects on blood pressure mechanisms mimicked those of the snake’s venom. When the cardiovascular juggernaut alighted in Sao Paulo, Brazil, for a major congress in 1984, there was even an opportunity for delegates to visit a snake farm and see the beast in all its glory.
“The discovery of the ACE inhibitors and the creation…
Featured
Treatment of ACEi-induced angioedema
ACE-inhibitor induced angioedema (ACEI-AAG) accounts for about a third of angioedema cases presenting to the emergency department. ACE inhibitors are increasingly popular, with the new JNC 8 guidelines up-grading them to a first-line drug for hypertension.
Articles of Interest
Lisinopril Not Working? Reasons Your Blood Pressure Medication Might Not Be Working
In this article, we will focus on why a drug such as lisinopril might not work to help treat a person’s blood pressure, discussing the alternative and the possible side effects of taking blood pressure medication.
Lisinopril Side Effects Can Be Life Threatening: Beware Angioedema and ACE Inhibitors!
Lisinopril and other ACE inhibitors can cause a serious complication: angioedema. The face and neck swelling of angioedema could result in death.
Lisinopril: A Comprehensive Guide to One of the Most Common Blood Pressure Medications
Lisinopril has earned its place as one of the most prescribed and trusted medications in modern cardiovascular medicine. Its versatility, efficacy, affordability, and once-daily dosing make it a cornerstone in the treatment of high blood pressure, heart failure, and diabetic kidney disease. However, like all medications, it’s not for everyone.
The clinical pharmacology of lisinopril
Lisinopril produces a smooth, gradual blood pressure (BP) reduction in hypertensive patients without affecting heart rate or cardiovascular reflexes. The antihypertensive effect begins within 2 h, peaks around 6 h, and lasts for at least 24 h.
What Is an ACE Inhibitor Cough?
Bradykinin relaxes blood vessels, helps the kidneys remove excess sodium from the body and ultimately lowers blood pressure. But bradykinin plays other roles in the body and is also involved in inflammation. Normally, the ACE enzyme breaks down this helpful protein. But an ACE inhibitor prevents that from happening so that bradykinin can stick around to help regulate blood pressure. Some doctors theorize that bradykinin may accumulate in the airways and cause a cough.
Resources
Lisinopril
In patients with uncomplicated essential hypertension not on diuretic therapy, the recommended initial dose is 10 mg once a day. Dosage should be adjusted according to blood pressure response. The usual dosage range is 20 mg to 40 mg per day administered in a single daily dose.
StatPearls
As a competitive ACE inhibitor, lisinopril prevents the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This activity reviews lisinopril's mechanism of action, highlighting its distinct pharmacokinetic parameters and half-life compared to other ACE inhibitors.
