Spironolactone
Spironolactone is a diuretic that was originally used to treat high blood pressure. It’s not a great blood pressure medication, but it was found to have useful antiandrogenic effects, which we use to treat acne - Aimee Paik MD
image by: Notes by Alice
HWN Suggests
Spironolactone “A Clear Winner” for Resistant Hypertension
In patients with poor blood pressure control despite treatment with a combination of three drugs (‘resistant hypertension’), addition of the diuretic spironolactone was significantly more effective than adding other blood pressure lowering drugs, according to results of the PATHWAY-2 trial... This establishes, for the first time, a clear hierarchy for drug treatment of resistant hypertension which should influence future treatment guidelines and clinical practice globally.
Articles of Interest
Effect of Spironolactone in Resistant Arterial Hypertension
In conclusion, the ASPIRANT-EXT trial confirms that spironolactone is an effective drug to lower both SBP and DBP in patients with resistant arterial hypertension with excellent safety over a short period. These results warrant more widespread use of spironolactone globally, considering its low cost and wide availability.
Efficacy and Safety of Spironolactone in Acute Heart Failure
In this randomized clinical trial, high-dose spironolactone use in acute heart failure was not associated with greater improvement in natriuretic peptide levels, symptoms, congestion, urine output, weight loss, or clinical outcomes than treatment with usual care.
Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent and human studies
Evidence suggests that spironolactone, a nonselective mineralocorticoid receptor (MR) antagonist, modulates alcohol seeking and consumption. Therefore, spironolactone may represent a novel pharmacotherapy for alcohol use disorder (AUD).
Spironolactone Effective for Lowering BP in Patients With Resistant Hypertension
A systematic review and network meta-analysis published in Cardiovascular Research found that spironolactone was the most effective treatment for reducing blood pressure (BP) among patients with resistant hypertension.
Spironolactone for hypertension
Spironolactone is a medication that has been used to treat high blood pressure since the 1960s. While there is some belief spironolactone reduces blood pressure, there are concerns due to the potential for this drug to cause adverse effects.
Spironolactone: 7 things you should know
Spironolactone belongs to the class of medicines called aldosterone receptor antagonists. Spironolactone may also be called a potassium-sparing diuretic.
Substance Profile: Spironolactone is Prohibited in Sport
Spironolactone is prohibited at all times under the World Anti-Doping Agency as a diuretic and masking agent. Canrenone is a derivative of spironolactone that is also prohibited. Both drugs are specific pharmacologic antagonists of aldosterone (a hormone that affects the body’s ability to regulate blood pressure), that cause increased amounts of sodium and water to be excreted, while potassium loss is minimized.
The story of spironolactones from 1957 to now: from sodium balance to inflammation
After the discovery of aldosterone (1953), many synthetic steroids were tested for their ability to block the sodium retaining and potassium excreting effect of synthetic mineralocorticoids in adrenalectomized rats. In the same years Kagawa discovered that 17-spirolactone steroids were effective to block mineralocorticoid effects...
Resources
StatPearls
Spironolactone is a medication used in the management and treatment of hypertension and heart failure with some indications aside from cardiovascular disease. It is in the mineralocorticoid receptor antagonist class of drugs.
