Phentolamine Mesylate

Health care providers might also administer phentolamine mesylate simultaneously with norepinephrine. The hormone notoriously causes tissue damage at the injection site and the alpha-blocker prevents this occurrence - Maggie J. Hall

Phentolamine Mesylate

image by: Rishi Kumar, MD

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Phentolamine Use in Hypertensive Crisis

Conditions producing hypertensive crisis from catecholamine surges (phenylephrine overdose, cocaine, tyramine interactions, pheochromocytoma) can be treated with phentolamine

Phentolamine is a nonspecifc alpha blocking agent which produces peripheral vasodilation with a resultant fall in blood pressure in most patients.

Other uses include extravasation of some vasopressors (e.g. norepineprhine)

May see an increase in HR after administration (once alpha blockade is established, beta-blocker can be administered)

Dose: 5-15 mg IV/IM Duration: 30-45 minutes

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Last Updated : Thursday, April 21, 2022