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4 Dicyclomine Interactions You Should Know About

Dicyclomine isn’t commonly used. In fact, the American College of Gastroenterology doesn’t recommend dicyclomine for IBS. They believe there isn’t enough research to support its use. Still, it’s important to know about possible drug interactions with dicyclomine. Some reactions just require more monitoring. But others can be serious and should be avoided.

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 Dicyclomine interactions to avoid

To avoid potentially dangerous side effects, it is important to know that dicyclomine interacts with certain diuretics, anticonvulsants, pain medication, dementia treatments, potassium supplements, and cannabinoids.

Articles of Interest

Bentyl/Dicyclomine is the most messed up drug I've ever taken

My GI doc gave me Bentyl (but I got the generic version) yesterday and I took it last nite for the first time. Oh my god. I read the side effects, made sure I was aware of what might possibly happen, and I swallowed it. I had the worst drug experience I've ever had.About 20 minutes after it went down my throat, I started having dissociative feelings.

Dicyclomine: 7 things you should know

Dry mouth, dizziness, blurred vision, inability to sweat, nausea, light-headedness, drowsiness, weakness, and nervousness are the most common side effects.

Exploring Dicyclomine (Bentyl): Uses, Benefits, And Important Information

Dicyclomine has several medical applications beyond the treatment of IBS. It is also used to manage various other digestive-related conditions, including spastic colon, diverticulosis, and gastrointestinal hypermotility.

Prenatal exposure to anti-nausea drug in ‘60s, ‘70s tied to increased risk of colorectal cancer

Incidence rates of colorectal cancer are increasing among adults born in and after the 1960s, which Murphy said implicates pregnancy-related exposures introduced at that time as risk factors. Dicyclomine – used to treat spasms caused by irritable bowel syndrome – was initially included in Bendectin, a drug prescribed during pregnancy in the 1960s to prevent nausea and vomiting.

Problematic dicyclomine use: A case report and narrative review

Anticholinergic agents, especially dicyclomine, are commonly used as antispasmodic drugs. Dicyclomine has high central nervous system penetration and produces central anticholinergic effects apart from the peripheral effect.

What is Dicyclomine Taken For? Uses, Dosage, & Side Effects

This medication can cause serious health problems such as heat stroke, gut problems, psychosis, drowsiness, dizziness, and blurred vision.

Resources

National Library of Medicine

Dicyclomine (dye sye' kloe meen) is synthetic tertiary amine, antispasmotic and anticholinergic agent which inhibits the muscarinic actions of acetylcholine on autonomic nerve endings, decreasing gastrointestinal secretions and intestinal motility. Dicyclomine has broad activity against muscarinic acetylcholine receptors, but has been used largely for gastrointestinal conditions including peptic ulcer disease and gastrointestinal conditions associated with pain and spasm. Dicyclomine was approved for use in the United States for the treatment of peptic ulcer disease in 1996, but is now more commonly used as an antispasmotic to treat irritable bowel syndrome.

PubChem

Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome. Though it is commonly prescribed, its recommendation may have been based on a small amount of evidence and so its prescription is becoming less favourable. Dicyclomine was granted FDA approval on 11 May 1950.