Itraconazole (Sporanox)
By no means is anyone a slob who has toenail fungus, but anyone who has it faces an uphill battle to get rid of it. It’s a battle because fungus is everywhere in our environment - State Journal-Register
HWN Suggests
Fungal Toenails- What are your oral options?
Itraconazole, sold under the brand name Sporanox, is another effective oral antifungal for treating toenail fungus. It is indicated for onychomycosis caused by dermatophytes, yeasts and moulds. Itraconazole is usually administered in pulse therapy, with the medication taken for one week per month over several months. Effectiveness: Itraconazole has been shown to have a success rate of about 60-70%, making it a reliable treatment option with potentially fewer and less severe side effects than terbinafine. Contraindications: Itraconazole should not be used during pregnancy and in patients with heart failure or those on certain medications that can interact, such as specific cholesterol-lowering…Featured
What is the appropriate dosing regimen for Itraconazole (Sporanox) in the treatment of onychomycosis?
Itraconazole should be prescribed at a dose of 200 mg per day for 12 weeks continuously, or alternatively as pulse therapy at a dose of 400 mg per day for 1 week per month, with 2 pulses recommended for fingernail onychomycosis and 3 pulses for toenail onychomycosis, as stated in the British Association of Dermatologists' guidelines for the management of onychomycosis 2014
Articles of Interest
Efficacy and safety of itraconazole in the long-term treatment of onychomycosis
In conclusion, itraconazole was at least as effective as griseofulvin in the treatment of onychomycosis. The itraconazole group continued to improve after the treatment was stopped. The results show that itraconazole 100 mg/day is safe and efficient in the long-term treatment of fungal nail infections.
Compare Sporanox vs. Econazole
Itraconazole (Sporanox) capsule is used to treat various fungal infections. You might have to take it for several weeks or months. It interacts with many medications, which can lead to serious heart-related side effects. Econazole is a prescription antifungal medication that's applied to the skin to treat certain fungal skin infections, such as ringworm, jock itch, and athlete's foot.
Compare Sporanox vs. Terbinafine
Itraconazole (Sporanox) capsule is used to treat various fungal infections. You might have to take it for several weeks or months. It interacts with many medications, which can lead to serious heart-related side effects. Terbinafine is a first-choice treatment option for fingernail and toenail fungus. It's available as once-daily tablets, but treatment can take many weeks. Common side effects of terbinafine include headache, rash, diarrhea, and upset stomach. Terbinafine can have interactions with other medications, including certain antidepressants, beta-blockers, and some medications that treat an irregular heart rhythm.
Resources
DailyMed
The recommended dosing regimen is 2 treatment pulses, each consisting of 200 mg (2 capsules) b.i.d. (400 mg/day) for 1 week. The pulses are separated by a 3-week period without SPORANOX ®.
Sporanox
SPORANOX® is the brand name for itraconazole, an azole antifungal agent. Itraconazole is a 1:1:1:1 racemic mixture of four diastereomers (two enantiomeric pairs), each possessing three chiral centers. It may be represented by the following structural formula and nomenclature...
StatPearls
In addition to treating systemic infections, itraconazole can also treat superficial fungal infections like onychomycosis, which has FDA approval. However, the cure rate of onychomycosis with itraconazole therapy is only 63%.
